Evidence map›Paper›PMID 30150424›Full record

ArticleIn vivo (Athens, Greece)

Chronic Nicotine Exposure Reduces Antioxidant Function of Simvastatin in Renal Proximal Tubule Cells.

Istvan Arany, Tibor Fülöp, Mehul Dixit

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Istvan AranyDivision of Pediatric Nephrology, Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, U.S.A. iarany@umc.edu.
Tibor FülöpDivision of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC, U.S.A.
Mehul DixitDivision of Pediatric Nephrology, Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, U.S.A.
University of Mississippi Medical Center · USMedical University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimWe have previously reported that simvastatin exhibits antioxidant properties via extracellular signal-regulated kinase (ERK)/cAMP-response element binding (CREB) protein-dependent induction of heme oxygenase-1 (HO1) and chronic nicotine exposure inhibits ERK/CREB signaling in renal proximal tubule cells (through p66shc). Herein, whether nicotine dampens simvastatin-dependent HO1 induction was determined. MATERIALS AND

methodsRenal proximal tubule (NRK52E) cells were pre-treated with 200 μM nicotine for 24 h followed by 10 μM simvastatin. Promoter activity of HO1 and manganese superoxide dismutase (MnSOD) and activation of CREB and ERK (via ELK1) were determined in luciferase reporter assays. CREB and p66shc were modulated via genetic means.

resultsNicotine suppressed simvastatin-dependent activation of HO1 and MnSOD promoters and activity of CREB and ELK1 via p66shc. Overexpression of CREB or knockdown of p66shc restored simvastatin-dependent induction of HO1 and MnSOD in the presence of nicotine.

conclusionAntioxidant efficiency of simvastatin might be significantly lessened in smokers/E-cigarette users.

Indexed as

AnimalsAntioxidantsCell LineCyclic AMP Response Element-Binding ProteinEpithelial CellsExtracellular Signal-Regulated MAP KinasesGene Expression RegulationHeme Oxygenase-1Hydroxymethylglutaryl-CoA Reductase InhibitorsKidney Tubules, ProximalNicotinePromoter Regions, GeneticRatsSimvastatinSmokingSrc Homology 2 Domain-Containing, Transforming Protein 1AntioxidantsCyclic AMP Response Element-Binding ProteinExtracellular Signal-Regulated MAP KinasesHeme Oxygenase-1Hydroxymethylglutaryl-CoA Reductase InhibitorsNicotineShc1 protein, ratSimvastatinSrc Homology 2 Domain-Containing, Transforming Protein 1Superoxide DismutaseantioxidantCREBERKHO1MnSODnicotinep66shcrenalSimvastatin

Identifiers

PMID30150424
PMCPMC6199611
OpenAlexW2889195239

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.