ArticleNature communications2018
The effect of maternal care on gene expression and DNA methylation in a subsocial bee.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 72 citations in OpenAlex.
- The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026Review
- Developmental and environmental stability of candidate reference genes in the wild bee ceratina calcarata.Scientific reports · 2025Article
- Transcriptomic correlates of nutritional manipulation in a facultatively social bee.The Journal of experimental biology · 2025Article
- Exploring the genetics of social behaviour in C. calcarata.Scientific reports · 2025Article
- Gene body methylation evolves during the sustained loss of parental care in the burying beetle.Nature communications · 2024Article
- Potential Role of DNA Methylation as a Driver of Plastic Responses to the Environment Across Cells, Organisms, and Populations.Genome biology and evolution · 2024Article
- The effects of maternal care on the developmental transcriptome and metatranscriptome of a wild bee.Communications biology · 2023Article
- Brain Gene Expression of Foraging Behavior and Social Environment in Ceratina calcarata.Genome biology and evolution · 2023Article
- Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity.BMC biology · 2023Article
- Molecular patterns and processes in evolving sociality: lessons from insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Comparative metagenomics reveals expanded insights into intra- and interspecific variation among wild bee microbiomes.Communications biology · 2022Article
- Changes in gene body methylation do not correlate with changes in gene expression in Anthozoa or Hexapoda.BMC genomics · 2022Article
- Review
- Review
- The role of epigenetics, particularly DNA methylation, in the evolution of caste in insect societies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Insects Provide Unique Systems to Investigate How Early-Life Experience Alters the Brain and Behavior.Frontiers in behavioral neuroscience · 2021Review
- Intergenerational transfer of DNA methylation marks in the honey bee.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Lineage and Parent-of-Origin Effects in DNA Methylation of Honey Bees (Apis mellifera) Revealed by Reciprocal Crosses and Whole-Genome Bisulfite Sequencing.Genome biology and evolution · 2020Article
- Bumblebee Workers Show Differences in Allele-Specific DNA Methylation and Allele-Specific Expression.Genome biology and evolution · 2020Article
- Developmental plasticity shapes social traits and selection in a facultatively eusocial bee.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental plasticity describes the influence of environmental factors on phenotypic variation. An important mediator of developmental plasticity in many animals is parental care. Here, we examine the consequences of maternal care on offspring after the initial mass provisioning of brood in the small carpenter bee, Ceratina calcarata. Removal of the mother during larval development leads to increased aggression and avoidance in adulthood. This corresponds with changes in expression of over one thousand genes, alternative splicing of hundreds of genes, and significant changes to DNA methylation. We identify genes related to metabolic and neuronal functions that may influence developmental plasticity and aggression. We observe no genome-wide association between differential DNA methylation and differential gene expression or splicing, though indirect relationships may exist between these factors. Our results provide insight into the gene regulatory context of DNA methylation in insects and the molecular avenues through which variation in maternal care influences developmental plasticity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.