Evidence map›Paper›PMID 30154312›Full record

ReviewInternational journal of molecular sciences2018

Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers.

Meng Cheng, Stephanie Michalski, Ramakrishna Kommagani

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meng ChengCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA. meng.cheng@wustl.edu.
Stephanie MichalskiCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA. saemichalski@gmail.com.
Ramakrishna KommaganiCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA. kommagani@wustl.edu.

Funding

GREB1 Action in Endometrial Function and DysfunctionR00HD080742 · NICHD · WASHINGTON UNIVERSITY · PI KOMMAGANI, RAMAKRISHNA · 2017 to 2019
$702k
GREB1 Action in Endometrial Function and DysfunctionK99HD080742 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI KOMMAGANI, RAMAKRISHNA · 2015 to 2016
$221k
National Institutes of Health R00 HD080742NICHD NIH HHS K99 HD080742NICHD NIH HHS R00 HD080742
6 · The paper itself

Abstract

Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance. Thus, we need to define the downstream effectors of sex hormones in order to develop new treatment strategies for these cancers. Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1).

Indexed as

Gene Expression Regulation, NeoplasticAnimalsBreast NeoplasmsFemaleHormonesHumansNeoplasm ProteinsReceptors, Cytoplasmic and NuclearReceptors, SteroidSignal TransductionSteroidsStructure-Activity RelationshipTranslational Research, BiomedicalGREB1 protein, humanHormonesNeoplasm ProteinsReceptors, Cytoplasmic and NuclearReceptors, SteroidSteroidsandrogenbreast cancerestrogenGREB1ovarian cancerprogesteroneprostate cancersteroid hormone

Identifiers

PMID30154312
PMCPMC6163654

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.