Evidence map›Paper›PMID 30156434›Full record

ArticleAIDS research and human retroviruses2019

Insulin Resistance in South African Youth Living with Perinatally Acquired HIV Receiving Antiretroviral Therapy.

Lisa J Frigati, Jennifer Jao, Sana Mahtab, Nana-Akua Asafu Agyei, Mark F Cotton, Landon Myer, Heather J Zar

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Endothelial Dysfunction in South African Youth Living With Perinatally Acquired Human Immunodeficiency Virus on Antiretroviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lisa J Frigati1 Department of Paediatrics and Child Health, Research Centre for Adolescent and Child Health University of Cape Town, Cape Town, South Africa.
Jennifer Jao3 Department of Medicine, Division of Infectious Diseases, Department of Obstetrics, Gynaecology and Reproductive Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Sana Mahtab1 Department of Paediatrics and Child Health, Research Centre for Adolescent and Child Health University of Cape Town, Cape Town, South Africa.
Nana-Akua Asafu Agyei1 Department of Paediatrics and Child Health, Research Centre for Adolescent and Child Health University of Cape Town, Cape Town, South Africa.
Mark F Cotton2 Department of Paediatrics and Child Health, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa.
Landon Myer4 Division of Epidemiology and Biostatistics School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Heather J Zar1 Department of Paediatrics and Child Health, Research Centre for Adolescent and Child Health University of Cape Town, Cape Town, South Africa.

Funding

Cape Town Adolescent Antiretroviral Cohort (CTAAC)R01HD074051 · NICHD · UNIVERSITY OF CAPE TOWN · PI ZAR, HEATHER JOY · 2012 to 2016
$3.0M
NICHD NIH HHS R01 HD074051
6 · The paper itself

Abstract

To investigate the prevalence of and risk factors for insulin resistance (IR) in a cohort of youth living with perinatally acquired HIV (YLPHIV) receiving antiretroviral treatment (ART). A cross-sectional analysis of IR in YLPHIV and age-matched HIV-uninfected youth enrolled in the Cape Town Adolescent Antiretroviral Cohort. South African youth ages 9-14 years, with perinatally acquired HIV who were on ART for >6 months and age-matched HIV-uninfected adolescents, were eligible. The homeostatic model assessment of insulin resistance (HOMA-IR), calculated from fasting insulin and glucose measurements at enrollment, was used to assess IR. Multiple linear regression was used to examine adjusted associations between HOMA and HIV-related and traditional cardiovascular risk factors. Of 448 adolescents, 385 (85.9%) were YLPHIV; median age was 12.1 years [interquartile range (IQR): 10.8-13.5], and 50.4% were female. Median duration on ART was 7.5 (IQR: 4.5-9.2) years. The prevalence of IR in YLPHIV was 18%. Among YLPHIV, waist circumference (ß = 0.01, p = .01), hypertriglyceridemia (ß = 0.07, p = .01), CD4 count >500 cells/mm

Indexed as

Insulin ResistanceAdolescentAnti-Retroviral AgentsChildCross-Sectional StudiesFemaleHIV InfectionsHumansMalePrevalenceRisk FactorsSouth AfricaAnti-Retroviral Agentsinsulin resistancemetabolic syndromesub-Saharan Africayouth living with perinatally acquired HIV

Identifiers

PMID30156434
PMCPMC6343194

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.