SynthesisBMC surgery2018
A systematic review on the use of topical hemostats in trauma and emergency surgery.
Synthesis in BMC surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04357483 (Randomized Controlled Study to Evaluate the Effect of Thrombin-containing Collagen-based Hemostatic Matrix on Prevention of Pancreatic Fistula After Pancreatecomy), which is not on this map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Study to Evaluate the Effect of Thrombin-containing Collagen-based Hemostatic Matrix on Prevention of Pancreatic Fistula After Pancreatecomy
Who cites it
66 citing papers in PubMed, 159 citations in OpenAlex.
- Application of S-100 absorbable hemostatic patch in endonasal endoscopic dacryocystorhinostomy: A randomized controlled trial.Indian journal of ophthalmology · 2025Trial
- Trial
- A Study of Safety and Effectiveness of Evicel Fibrin Sealant as an Adjunctive Hemostat in Pediatric Surgery.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2024Trial
- Safety and Hemostatic Effectiveness of SURGICEL® Powder in Mild and Moderate Intraoperative Bleeding.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisTrial
- Trial
- Effect of a water-soluble alkylene oxide copolymer based bone hemostat in cardiac surgery: a prospective, multicenter, single-arm study.Journal of cardiothoracic surgery · 2026Article
- Development of a Rapid-Acting Oxidized Regenerated Cellulose-Based Powder for Hemostatic Applications.ACS omega · 2026Article
- The changing patient profile: A retrospective study of trends in perioperative bleeding management and challenges in surgical care.Surgery in practice and science · 2026Article
- From Biomaterial Innovation to Surgical Practice: A Systematic Review of RADA16 Self-Assembling Peptide Hydrogel in Otolaryngology and Head & Neck Surgery.Journal of clinical medicine · 2026Review
- Assessment of collagen hemostatic membrane and sponge in alveolar sockets: A quasi-experimental prospective clinical study.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Should we consider styptics in patients with bleeding disorders?Research and practice in thrombosis and haemostasis · 2026Article
- Injectable Deep Eutectic Solvent-Based Ionic Gel With Rapid Gelation and Broad Hemostatic Functionality.Advanced healthcare materials · 2026Article
- Safety and efficacy of flowable microfibrillar collagen hemostat in an ovine model of lumbar laminectomy and open durotomy compared with the gelatin-thrombin hemostatic matrix and control.Frontiers in surgery · 2026Article
- Development of a 50% (w/v) aluminium chloride hexahydrate solution as haemostatic agent.European journal of hospital pharmacy : science and practice · 2025Article
- Article
- Blood Management and Conservation During Adult Spine Deformity Surgery.Global spine journal · 2025Article
- Article
- Oxidized regenerated cellulose powder reduces perioperative bleeding and thigh swelling in total hip arthroplasty: a prospective interventional study.Journal of orthopaedic surgery and research · 2025Article
- Recent Trends in the Application of Cellulose-Based Hemostatic and Wound Healing Dressings.Journal of functional biomaterials · 2025Review
- Covalently reactive microparticles imbibe blood to form fortified clots for rapid hemostasis and prevention of rebleeding.Nature communications · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA wide variety of hemostats are available as adjunctive measures to improve hemostasis during surgical procedures if residual bleeding persists despite correct application of conventional methods for hemorrhage control. Some are considered active agents, since they contain fibrinogen and thrombin and actively participate at the end of the coagulation cascade to form a fibrin clot, whereas others to be effective require an intact coagulation system. The aim of this study is to provide an evidence-based approach to correctly select the available agents to help physicians to use the most appropriate hemostat according to the clinical setting, surgical problem and patient's coagulation status.
methodsThe literature from 2000 to 2016 was systematically screened according to PRISMA [Preferred Reporting Items for Systematic Reviews and Meta-Analyses] protocol. Sixty-six articles were reviewed by a panel of experts to assign grade of recommendation (GoR) and level of evidence (LoE) using the GRADE [Grading of Recommendations Assessment, Development and Evaluation] system, and a national meeting was held.
resultsFibrin adhesives, in liquid form (fibrin glues) or with stiff collagen fleece (fibrin patch) are effective in the presence of spontaneous or drug-induced coagulation disorders. Mechanical hemostats should be preferred in patients who have an intact coagulation system. Sealants are effective, irrespective of patient's coagulation status, to improve control of residual oozing. Hemostatic dressings represent a valuable option in case of external hemorrhage at junctional sites or when tourniquets are impractical or ineffective.
conclusionsLocal hemostatic agents are dissimilar products with different indications. A knowledge of the properties of each single agent should be in the armamentarium of acute care surgeons in order to select the appropriate product in different clinical conditions.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.