Evidence map›Paper›PMID 30158836›Full record

ArticleMediators of inflammation2018

Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients.

Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05298163 (Effects of Calcitriol on Podocytes in Diabetic Kidney Disease Patients), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05298163 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effects of Calcitriol on Podocytes in Diabetic Kidney Disease Patients: Assessment of Urine Podocin, Urine Nephrin, Urine Interleukin-6, Urine KIM-1, Plasma Renin, and Albuminuria

TypeinterventionalSponsorIndonesia UniversityRan2022 to 2022Enrolled120ConditionsDiabetic Kidney DiseaseArmsCalcitriol capsules, Placebo
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  9. Urinary L-FABP: A Novel Biomarker for Evaluating Diabetic Nephropathy Onset and Progression. A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
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  12. Article
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  14. Sigma-1 Receptor as a Novel Therapeutic Target in Diabetic Kidney Disease.International journal of molecular sciences · 2024
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Agnieszka ŻyłkaSt. Queen Jadwiga Clinical District Hospital No. 2, 35-301 Rzeszów, Poland.
Paulina DumnickaDepartment of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland.ORCID 0000-0003-3667-857X
Beata Kuśnierz-CabalaDepartment of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, Poland.ORCID 0000-0001-8639-5688
Agnieszka Gala-BłądzińskaSt. Queen Jadwiga Clinical District Hospital No. 2, 35-301 Rzeszów, Poland.
Piotr CeranowiczDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Kraków, Poland.ORCID 0000-0003-3478-0108
Jakub KucharzDepartment of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland.
Anna Ząbek-AdamskaDiagnostic Department, University Hospital, 31-501 Kraków, Poland.
Barbara MaziarzDepartment of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, Poland.
Ryszard DrożdżDepartment of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland.
Marek KuźniewskiChair and Department of Nephrology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, Poland.
Jagiellonian University · PLThe Maria Sklodowska-Curie National Research Institute of Oncology · PLUniversity of Rzeszów · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR). Among 80 T2DM patients with median eGFR of 92.4 ml/min/1.73 m

Indexed as

AlbuminuriaBiomarkersCreatinineCross-Sectional StudiesCystatin CDiabetes Mellitus, Type 2Diabetic NephropathiesHepatitis A Virus Cellular Receptor 1HumansImmunoglobulin GLipocalin-2Retrospective StudiesTransferrinUromodulinBiomarkersCreatinineCystatin CHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Immunoglobulin GLipocalin-2TransferrinUromodulin

Identifiers

PMID30158836
PMCPMC6109534
OpenAlexW2885926053

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.