ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2019
Renal function in relation to low-level environmental lead exposure.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02243904 (Study for Promotion of Health in Recycling Lead), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study for Promotion of Health in Recycling Lead
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Blood Lead Level and Renal Impairment among Adults: A Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- The independent and interactive effects of heavy metal pollution and vitamin D deficiency on early kidney injury indicators: analysis of the National Health and Nutrition Examination Survey 2001-2004.BMC public health · 2025Article
- METTL3 mediated m6A modification of HKDC1 promotes renal injury and inflammation in lead nephropathy.International journal of biological sciences · 2025Article
- Blood pressure and renal function responses in workers exposed to lead for up to six years.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Adipose tissue is associated with kidney function parameters.Scientific reports · 2023Article
- Public and occupational health risks related to lead exposure updated according to present-day blood lead levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Two-Year Responses of Renal Function to First Occupational Lead Exposure.Kidney international reports · 2022Article
- Association of albumin to creatinine ratio with urinary arsenic and metal exposure: evidence from NHANES 2015-2016.International urology and nephrology · 2022Article
- Plasma Vitamin BNutrients · 2021Article
- Interpretation of Population Health Metrics: Environmental Lead Exposure as Exemplary Case.Hypertension (Dallas, Tex. : 1979) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous studies suggested that occupational or environmental exposure to lead adversely affects renal function. However, most studies lost relevance because of the substantially lower current environmental lead exposure and all relied on serum creatinine to estimate glomerular filtration. We investigated the association of estimated glomerular filtration rate (eGFR), estimated from serum creatinine, cystatin C or both, with blood lead (BPb) using the baseline measurements of the ongoing Study for Promotion of Health in Recycling Lead (SPHERL; NCT02243904) in newly hired workers prior to significant occupational lead exposure.
methodsAmong 447 men (participation rate, 82.7%), we assessed the association of eGFR and the urinary albumin-to-creatinine ratio (ACR) with BPb across thirds of the BPb distribution using linear regression analysis. Fully adjusted models accounted for age, blood pressure, body mass index, the waist-to-hip ratio, smoking, the total-to-high-density-lipoprotein ratio, plasma glucose, serum γ-glutamyltransferase and antihypertensive drug treatment.
resultsAge averaged 28.7 (SD, 10.2) years (range, 19.1-31.8). Geometric mean BPb concentration was 4.34 μg/dL (5th-95th percentile interval, 0.9-14.8). In unadjusted and adjusted analyses, eGFR estimated from serum creatinine [mean (SD), 105.26 (15.2) mL/min/1.73 m2], serum cystatin C [mean (SD), 127.8 (13.8) mL/min/1.73 m2] or both [mean (SD), 111.9 (14.8) mL/min/1.73 m2] was not associated with BPb (P ≥ 0.36), whereas ACR [geometric mean, 4.32 mg/g (5th-95th percentile interval, 1.91-12.50)] was lower with higher BPb.
conclusionsAt the BPb levels observed in this study, there was no evidence for an association between renal function and lead exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.