Evidence map›Paper›PMID 30170601›Full record

ReviewCardiovascular diabetology2018

Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies.

Raminderjit Kaur, Manpreet Kaur, Jatinder Singh

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular diabetology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 375 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
375citing papers in PubMed, 7 pooled it
30.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

375 citing papers in PubMed, 7 syntheses or guidelines pooled it, 711 citations in OpenAlex.

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  8. Effect of insulin resistance on ticagrelor-versus clopidogrel-based dual antiplatelet therapy for secondary prevention of stroke in carriers ofCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
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315 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Raminderjit KaurDepartment of Molecular Biology & Biochemistry, Guru Nanak Dev University, Amritsar, Punjab, India.
Manpreet KaurDepartment of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.
Jatinder SinghDepartment of Molecular Biology & Biochemistry, Guru Nanak Dev University, Amritsar, Punjab, India. jatinterarora2009@gmail.com.
Guru Nanak Dev University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes, accounting for approximately 90-95% of the total diabetes cases worldwide. Besides affecting the ability of body to use glucose, it is associated with micro-vascular and macro-vascular complications. Augmented atherosclerosis is documented to be the key factor leading to vascular complications in T2DM patients. The metabolic milieu of T2DM, including insulin resistance, hyperglycemia and release of excess free fatty acids, along with other metabolic abnormalities affects vascular wall by a series of events including endothelial dysfunction, platelet hyperactivity, oxidative stress and low-grade inflammation. Activation of these events further enhances vasoconstriction and promotes thrombus formation, ultimately resulting in the development of atherosclerosis. All these evidences are supported by the clinical trials reporting the importance of endothelial dysfunction and platelet hyperactivity in the pathogenesis of atherosclerotic vascular complications. In this review, an attempt has been made to comprehensively compile updated information available in context of endothelial and platelet dysfunction in T2DM.

Indexed as

Platelet ActivationVasoconstrictionAnimalsAtherosclerosisBiomarkersBlood GlucoseBlood PlateletsDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularFibrinolytic AgentsHumansHypoglycemic AgentsInflammation MediatorsOxidative StressPlatelet Aggregation InhibitorsBiomarkersBlood GlucoseFibrinolytic AgentsHypoglycemic AgentsInflammation MediatorsPlatelet Aggregation InhibitorsHyperglycemiaInflammationInsulin resistanceOxidative stressVascular complications

Identifiers

PMID30170601
PMCPMC6117983
OpenAlexW2889111495

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.