Evidence map›Paper›PMID 30185408›Full record

ArticleThe EMBO journal2018

Pool size estimations for dense-core vesicles in mammalian CNS neurons.

Claudia M Persoon, Alessandro Moro, Joris P Nassal, Margherita Farina, Jurjen H Broeke, Swati Arora, Natalia Dominguez, Jan Rt van Weering, Ruud F Toonen, Matthijs Verhage

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Neuroendocrine Control of Synaptic Transmission by PHAC-1 inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Maximal Fusion Capacity and Efficient Replenishment of the Dense Core Vesicle Pool in Hippocampal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  15. Article
  16. Article
  17. Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  18. Article
  19. The role of microRNAs in depression.Frontiers in pharmacology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Claudia M PersoonClinical Genetics, VU Medical Center, Amsterdam, The Netherlands.
Alessandro MoroClinical Genetics, VU Medical Center, Amsterdam, The Netherlands.
Joris P NassalClinical Genetics, VU Medical Center, Amsterdam, The Netherlands.
Margherita FarinaDepartment of Functional Genomics, Faculty of Exact Science, Center for Neurogenomics and Cognitive Research, VU University Amsterdam and VU Medical Center, Amsterdam, The Netherlands.
Jurjen H BroekeClinical Genetics, VU Medical Center, Amsterdam, The Netherlands.
Swati AroraDepartment of Functional Genomics, Faculty of Exact Science, Center for Neurogenomics and Cognitive Research, VU University Amsterdam and VU Medical Center, Amsterdam, The Netherlands.ORCID 0000-0002-9442-3359
Natalia DominguezClinical Genetics, VU Medical Center, Amsterdam, The Netherlands.
Jan Rt van WeeringClinical Genetics, VU Medical Center, Amsterdam, The Netherlands.
Ruud F ToonenDepartment of Functional Genomics, Faculty of Exact Science, Center for Neurogenomics and Cognitive Research, VU University Amsterdam and VU Medical Center, Amsterdam, The Netherlands ruud.toonen@cncr.vu.nl matthijs@cncr.vu.nl.
Matthijs VerhageClinical Genetics, VU Medical Center, Amsterdam, The Netherlands ruud.toonen@cncr.vu.nl matthijs@cncr.vu.nl.ORCID 0000-0002-2514-0216
Amsterdam UMC Location Vrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropeptides are essential signaling molecules transported and secreted by dense-core vesicles (DCVs), but the number of DCVs available for secretion, their subcellular distribution, and release probability are unknown. Here, we quantified DCV pool sizes in three types of mammalian CNS neurons

Indexed as

AxonsCorpus StriatumHippocampusNeuritesSecretory VesiclesSynapsesAnimalsMicedense‐core vesiclespool sizesrelease probabilitysecretion

Identifiers

PMID30185408
PMCPMC6187028
OpenAlexW2890206927

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.