Evidence map›Paper›PMID 30201804›Full record

ArticleMolecular and cellular biology2018

Adaptation to Endoplasmic Reticulum Stress Requires Transphosphorylation within the Activation Loop of Protein Kinases Kin1 and Kin2, Orthologs of Human Microtubule Affinity-Regulating Kinase.

Chandrima Ghosh, Leena Sathe, Joel David Paprocki, Valerica Raicu, Madhusudan Dey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. The regulatory landscape of the yeast phosphoproteome.Nature structural & molecular biology · 2023
    Article
  2. Detection of HAC1 mRNA Splicing by RT-PCR in Saccharomyces cerevisiae.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chandrima GhoshDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Leena SatheDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Joel David PaprockiDepartment of Physics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Valerica RaicuDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Madhusudan DeyDepartment of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA deym@uwm.edu.
University of Wisconsin–Milwaukee · US

Funding

Regulating the Unfolded Protein Response in YeastR01GM124183 · NIGMS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI DEY, MADHUSUDAN · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM124183
6 · The paper itself

Abstract

Perturbations in endoplasmic reticulum (ER) homeostasis, a condition termed ER stress, activate the unfolded protein response (UPR), an intracellular network of signaling pathways. Recently, we have shown that protein kinase Kin1 and its paralog, Kin2, in the budding yeast

Indexed as

Amino Acid SequenceCell MembraneEndoplasmic ReticulumEndoplasmic Reticulum StressHumansMembrane ProteinsMicrotubulesPhosphorylationProtein KinasesProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionUnfolded Protein ResponseKIN1 protein, S cerevisiaeKIN2 protein, S cerevisiaeMembrane ProteinsProtein KinasesProtein Serine-Threonine KinasesSaccharomyces cerevisiae Proteinsactivation loopER stressKin1Kin2phosphorylationprotein kinase

Identifiers

PMID30201804
PMCPMC6234288
OpenAlexW2889929007

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.