Evidence map›Paper›PMID 30206173›Full record

ArticlemBio2018

Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency.

Eleonora Forte, Suchitra Swaminathan, Mark W Schroeder, Jeong Yeon Kim, Scott S Terhune, Mary Hummel

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 49 citations in OpenAlex.

  1. Mechanisms and Determinants of CMV Reactivation in Kidney Transplantation.International journal of molecular sciences · 2026
    Review
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  3. Review
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  5. Article
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  7. KAP1 in antiviral immunity: dual roles in viral silencing and immune regulation.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Hematopoietic stem cells and betaherpesvirus latency.Frontiers in cellular and infection microbiology · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eleonora ForteDepartment of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Suchitra SwaminathanDepartment of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Mark W SchroederDepartment of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jeong Yeon KimDepartment of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Scott S TerhuneDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Mary HummelDepartment of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA m-hummel@northwestern.edu.ORCID 0000-0001-6277-4405
Northwestern University · USMedical College of Wisconsin · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Precision Cell Isolation and Analysis CoreP01AI112522 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HUMMEL, MARY A · 2015 to 2019
$11.9M
Impact of HCMV proteins on viral replication and cellular signaling pathwaysR01AI083281 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI TERHUNE, SCOTT SLETTEN · 2011 to 2020
$3.2M
FACSAria SORP Cell SorterS10OD011996 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOOLSBY, CHARLES L. · 2012 to 2012
$482k
NCI NIH HHS P30 CA060553NIAID NIH HHS P01 AI112522NIAID NIH HHS R01 AI083281NIH HHS S10 OD011996
6 · The paper itself

Abstract

We used the Kasumi-3 model to study human cytomegalovirus (HCMV) latency and reactivation in myeloid progenitor cells. Kasumi-3 cells were infected with HCMV strain TB40/E

Indexed as

Cell DifferentiationVirus LatencyAntigens, CD34Ataxia Telangiectasia Mutated ProteinsCell Line, TumorCytomegalovirusFlow CytometryGene ExpressionGreen Fluorescent ProteinsHumansMyeloid CellsNF-kappa BRNA Processing, Post-TranscriptionalTripartite Motif-Containing Protein 28Tumor Necrosis Factor-alphaVirus ActivationAntigens, CD34Ataxia Telangiectasia Mutated ProteinsATM protein, humanGreen Fluorescent ProteinsNF-kappa BTRIM28 protein, humanTripartite Motif-Containing Protein 28Tumor Necrosis Factor-alphacytomegaloviruslatencyreactivation

Identifiers

PMID30206173
PMCPMC6134100
OpenAlexW2890706264

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.