Evidence map›Paper›PMID 30210276›Full record

ReviewFrontiers in neuroscience2018

Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events.

Aaron I Vinik, Carolina Casellini, Henri K Parson, Sheri R Colberg, Marie-Laure Nevoret

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 155 citations in OpenAlex.

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  9. Relationship Between Physical Activity and Autonomic Responses in Adults with Type 2 Diabetes.International journal of environmental research and public health · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aaron I VinikDivision of Endocrinology and Metabolism, Strelitz Diabetes Center and Neuroendocrine Unit, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, United States.
Carolina CaselliniDivision of Endocrinology and Metabolism, Strelitz Diabetes Center and Neuroendocrine Unit, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, United States.
Henri K ParsonDivision of Endocrinology and Metabolism, Strelitz Diabetes Center and Neuroendocrine Unit, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, United States.
Sheri R ColbergDepartment of Human Movement Sciences, Old Dominion University, Norfolk, VA, United States.
Marie-Laure NevoretVM BioPharma, Atlanta, GA, United States.
Eastern Virginia Medical School · USOld Dominion University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autonomic nervous system (ANS) imbalance manifesting as cardiac autonomic neuropathy in the diabetic population is an important predictor of cardiovascular events. Symptoms and signs of ANS dysfunction, such as resting heart rate elevations, diminished blood pressure responses to standing, and altered time and frequency domain measures of heart rate variability in response to deep breathing, standing, and the Valsalva maneuver, should be elicited from all patients with diabetes and prediabetes. With the recognition of the presence of ANS imbalance or for its prevention, a rigorous regime should be implemented with lifestyle modification, physical activity, and cautious use of medications that lower blood glucose. Rather than intensifying diabetes control, a regimen tailored to the individual risk of autonomic imbalance should be implemented. New agents that may improve autonomic function, such as SGLT2 inhibitors, should be considered and the use of incretins monitored. One of the central mechanisms of dysfunction is disturbance of the hypothalamic cardiac clock, a consequence of dopamine deficiency that leads to sympathetic dominance, insulin resistance, and features of the metabolic syndrome. An improvement in ANS balance may be critical to reducing cardiovascular events, cardiac failure, and early mortality in the diabetic population.

Indexed as

cardiac autonomic neuropathycardiovascular event predictiondiabetesdopamine deficiencyheart rate variabilityinsulin resistanceparasympatheticsympathetic

Identifiers

PMID30210276
PMCPMC6119724
OpenAlexW2889063318

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.