ArticleFrontiers in oncology2018
Applying an Exposome-Wide (ExWAS) Approach to Cancer Research.
Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Rethinking gastric carcinogenesis: a multiscale ecological model of risk beyondFrontiers in microbiology · 2026Review
- Feasibility and Acceptability of Assessing Personal Care Product Use and Exposure to Endocrine-Disrupting Chemicals Among Black and Hispanic Breast Cancer Survivors: A Pilot Study.International journal of environmental research and public health · 2025Article
- Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters.Environment international · 2025Article
- The need for a cancer exposome atlas: a scoping review.JNCI cancer spectrum · 2025Article
- Epidemiology of nasopharyngeal carcinoma: current insights and future outlook.Cancer metastasis reviews · 2024Review
- Landscape analysis of environmental data sources for linkage with SEER cancer patients database.Journal of the National Cancer Institute. Monographs · 2024Article
- Probing the digital exposome: associations of social media use patterns with youth mental health.NPP - digital psychiatry and neuroscience · 2024Article
- Enriching Real-world Data with Social Determinants of Health for Health Outcomes and Health Equity: Successes, Challenges, and Opportunities.Yearbook of medical informatics · 2023Article
- Methodological Challenges in Spatial and Contextual Exposome-Health Studies.Critical reviews in environmental science and technology · 2023Article
- Silicone wristbands as personal passive sampling devices: Current knowledge, recommendations for use, and future directions.Environment international · 2022Review
- Identifying the link between chemical exposures and breast cancer in African American women via integrated in vitro and exposure biomarker data.Toxicology · 2021Article
- An external exposome-wide association study of hypertensive disorders of pregnancy.Environment international · 2020Article
- A comprehensive analysis of racial disparities in chemical biomarker concentrations in United States women, 1999-2014.Environment international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional research approaches, including genome-wide association studies (GWAS), epigenome-wide association studies (EWAS) and Gene × Environment (G × E) studies are limited in their ability to handle the multiplicity of chemical and non-chemical toxicants to which people are exposed in the real world, over their life course, their impact on epigenomics and other biological systems, and their relationship to cancer onset, progression, and outcomes. Exposome-wide association study (ExWAS) provides a new approach for conceptualizing the roles and relationships of multiple chemical and non-chemical exposures in the etiology and progression of cancer at key developmental periods, over the life course, and across generations. ExWAS challenges us to consider the influence of both internal and external environment, chemical and non-chemical stressors, risk and protective factors, and spatial and temporal dimensions of exposures in our models of cancer incidence, outcomes, and disparities. Applying an ExWAS approach to cancer and cancer disparities research supports robust computational models and methods that will allow for analysis of the dynamic and complex interactions between genetics, epigenetics, and exposomics factors. In the coming months, we will spatially and temporally align environmental exposures with SCCS participant data from time of enrollment forward to move us closer to identifying complete exposure pathways that lead to cancer. In the future, we hope to link external sources of exposure to biomarkers of exposure, biomarkers of disease, disease phenotypes, and population level disparities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.