ArticleBlood2018
Bone marrow-specific loss of
Open access · bronzeAbstract read
In one paragraph
Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- KCTD15 deregulation is associated with alterations of the NF-κB signaling in both pathological and physiological model systems.Scientific reports · 2021Trial
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- Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated endocytosis of Notch.The Journal of cell biology · 2026Article
- Safety Assessment of Extracellular Vesicle-Based Therapy in Regenerative Dentistry.International journal of molecular sciences · 2026Review
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- Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation.Biomolecules · 2025Review
- TIMAP downregulation in Burkitt's lymphoma reveals key molecules and signaling pathways in B-cell lymphomagenesis.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Adaptor protein Abelson interactor 1 in homeostasis and disease.Cell communication and signaling : CCS · 2024Review
- NF-κB in biology and targeted therapy: new insights and translational implications.Signal transduction and targeted therapy · 2024Review
- Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity.Frontiers in immunology · 2024Article
- Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice.Experimental hematology · 2023Article
- Proximity proteomics reveals role of Abelson interactor 1 in the regulation of TAK1/RIPK1 signaling.Molecular oncology · 2023Article
- Effect of Penthorum Chinense Pursh Compound on AFB1-Induced Immune Imbalance via JAK/STAT Signaling Pathway in Spleen of Broiler Chicken.Veterinary sciences · 2023Article
- The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Deepening Our Understanding of the Factors Affecting Landscape of Myeloproliferative Neoplasms: What Do We Know about Them?Cancers · 2023Review
- ABI1-based expression signature predicts breast cancer metastasis and survival.Molecular oncology · 2022Article
- Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling.iScience · 2022Article
- TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling.Theranostics · 2022Article
- miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk.Leukemia · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 8 institutions in 3 countries.
Anna ChorzalskaSignal Transduction Laboratory, Division of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.
John MorganFlow Cytometry and Cell Sorting Core Facility, Roger Williams Medical Center, Providence, RI.
Nagib AhsanCenter of Biomedical Research Excellence (COBRE), Center for Cancer Research Development, Proteomics Core Facility, Rhode Island Hospital, Providence, RI.ORCID 0000-0003-2752-3795
Diana O TreabaDepartment of Pathology and Laboratory Medicine at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.ORCID 0000-0002-7346-9219
Adam J OlszewskiDivision of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.ORCID 0000-0002-6472-6658
Max PetersenSignal Transduction Laboratory, Division of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.ORCID 0000-0003-3179-4619
Nathan KingstonSignal Transduction Laboratory, Division of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.
Yan ChengDivision of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.
Kara LombardoDepartment of Pathology and Laboratory Medicine at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.
Christoph SchorlGenomics Core Facility, Brown University, Providence, RI.ORCID 0000-0001-6132-3581
Xiaoqing YuDepartment of Biostatistics, Yale School of Public Health, New Haven, CT.ORCID 0000-0002-3255-9285
Roberta ZiniCenter for Regenerative Medicine "Stefano Ferrari," Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0001-6657-0864
Annalisa PacilliCRIMM, Center for Research and Innovation for Myeloproliferative Neoplasms, AOU Careggi, and.
Alexander TepperSignal Transduction Laboratory, Division of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.
Jillian CoburnCenter of Biomedical Research Excellence (COBRE), Center for Cancer Research Development, Proteomics Core Facility, Rhode Island Hospital, Providence, RI.
Anita Hryniewicz-JankowskaCytobiochemistry Laboratory, Department of Biotechnology, University of Wroclaw, Wroclaw, Poland.
Ting C ZhaoCardiovascular Laboratory, Department of Surgery, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI.
Elena OanceaDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI; and.ORCID 0000-0001-9584-5230
John L ReaganDivision of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.ORCID 0000-0003-4877-6863
Olin LiangDivision of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.ORCID 0000-0002-2266-6722
Leszek KotulaDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY.ORCID 0000-0002-7977-7124
Peter J QuesenberryDivision of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.ORCID 0000-0002-7370-5787
Philip A GruppusoDepartment of Pediatrics, Brown University and Rhode Island Hospital, Providence, RI.ORCID 0000-0002-5125-2991
Rossella ManfrediniCenter for Regenerative Medicine "Stefano Ferrari," Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0003-0660-6110
Alessandro Maria VannucchiCRIMM, Center for Research and Innovation for Myeloproliferative Neoplasms, AOU Careggi, and.
Patrycja M DubieleckaSignal Transduction Laboratory, Division of Hematology/Oncology at Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI.ORCID 0000-0003-3987-0647
Brown University · USSUNY Upstate Medical University · USUniversity of Florence · ITUniversity of Modena and Reggio Emilia · ITBoston University · USRhode Island Hospital · USRoger Williams Medical Center · USYale University · US
Funding
Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI ROUNDS, SHARON IRENE SMITH · 2016 to 2025
$45.0MStem Cells and AgingP20GM119943 · NIGMS · RHODE ISLAND HOSPITAL · PI WEBB, ASHLEY E · 2017 to 2021
$10.6MTRANSFUSION BIOLOGY AND MEDICINET32HL066987 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI JOHN P MANIS · 2001 to 2026
$10.2MCOBRE Center for Cancer Research DevelopmentP30GM110759 · NIGMS · RHODE ISLAND HOSPITAL · PI RAMRATNAM, BHARAT · 2015 to 2019
$6.3MMechanism of PIN development in Abi1/Hssh3bp1 KO mouseR01CA161018 · NCI · UPSTATE MEDICAL UNIVERSITY · PI KOTULA, LESZEK · 2013 to 2017
$1.7MPredoctoral Training Program in Trans-Disciplinary Pharmacological SciencesT32GM077995 · NIGMS · BROWN UNIVERSITY · PI OANCEA, ELENA · 2010 to 2020
$1.7MNCI NIH HHS R01 CA161018NHLBI NIH HHS T32 HL066987NIGMS NIH HHS P20 GM119943NIGMS NIH HHS P30 GM110759NIGMS NIH HHS T32 GM077995NIGMS NIH HHS U54 GM115677
Abstract
Although the pathogenesis of primary myelofibrosis (PMF) and other myeloproliferative neoplasms (MPNs) is linked to constitutive activation of the JAK-STAT pathway, JAK inhibitors have neither curative nor MPN-stem cell-eradicating potential, indicating that other targetable mechanisms are contributing to the pathophysiology of MPNs. We previously demonstrated that Abelson interactor 1 (Abi-1), a negative regulator of Abelson kinase 1, functions as a tumor suppressor. Here we present data showing that bone marrow-specific deletion of
Indexed as
Gene DeletionAdaptor Proteins, Signal TransducingAnimalsBone MarrowCells, CulturedCell Self RenewalCytoskeletal ProteinsDown-RegulationFemaleHumansMiceMice, Inbred C57BLMice, TransgenicNF-kappa BPrimary MyelofibrosisSignal TransductionABI1 protein, humanAbi1 protein, mouseAdaptor Proteins, Signal TransducingCytoskeletal ProteinsNF-kappa Bsrc-Family KinasesSTAT3 Transcription Factor
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.