Evidence map›Paper›PMID 30232674›Full record

ArticleJournal of molecular neuroscience : MN2018

Genetic Variation of the Kalirin Gene is Associated with ICAS in the Chinese Population.

Meizheng Dang, Yue Song, Qunying Li, Chao Zhang, Yanqing Peng, Zhenli Wei, Pintong Huang

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meizheng DangDepartment of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Yue SongDepartment of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Qunying LiDepartment of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Chao ZhangDepartment of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Yanqing PengDepartment of Ultrasound, People's Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, China.
Zhenli WeiDepartment of Clinical Laboratory, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Pintong HuangDepartment of Ultrasound, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. huangpintong@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNZhejiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial atherosclerotic stenosis (ICAS) is one of the most common causes of ischemic stroke (IS), especially in recurrent patients. Several studies have demonstrated an intimate association between the genetic mutation of the KALRN gene and IS. The main aim of this study was to clarify the relationship between three single nucleotide polymorphisms (SNPs) of KALRN and ICAS in a northern Chinese population and further explore the underlining mechanism. The relationship between each SNP and ICAS and the related components were examined in five models (co-dominant, dominant, recessive, heterozygous, and additive). Multivariate logistic regression models were applied and adjusted for 10,000 permutation tests. Haplotype regression analysis was performed to determine the associations between haplotypes and the severity of ICAS. qRT-PCR was used to confirm the mRNA level of Kalirin. SNP rs6438833 of the Kalirin gene in the additive model was associated with ICAS (OR = 1.642, 95%CI: 1.129-2.388, P

Indexed as

Polymorphism, Single NucleotideAgedCarotid StenosisFemaleGuanine Nucleotide Exchange FactorsHaplotypesHumansIntracranial ArteriosclerosisMaleMiddle AgedProtein Serine-Threonine KinasesGuanine Nucleotide Exchange FactorsKALRN protein, humanProtein Serine-Threonine KinasesIntracranial atherosclerotic stenosisIschemic strokeKALRNSNP

Identifiers

PMID30232674
OpenAlexW2891165472

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.