Evidence map›Paper›PMID 30237160›Full record

ArticleDiabetes2018

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Evan D Rosen, Klaus H Kaestner, Rama Natarajan, Mary-Elizabeth Patti, Richard Sallari, Maike Sander, Katalin Susztak

Abstract read
In one paragraph

Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evan D RosenDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA ksusztak@pennmedicine.upenn.edu erosen@bidmc.harvard.edu.ORCID 0000-0003-4603-708X
Klaus H KaestnerDepartment of Genetics and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Rama NatarajanBeckman Research Institute of City of Hope, Duarte, CA.
Mary-Elizabeth PattiHarvard Medical School, Boston, MA.
Richard SallariBroad Institute, Cambridge, MA.
Maike SanderUniversity of California, San Diego, La Jolla, CA.
Katalin SusztakDepartment of Genetics and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA ksusztak@pennmedicine.upenn.edu erosen@bidmc.harvard.edu.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Inflammatory Gene Transcription In Diabetic ConditionsR01DK065073 · NIDDK · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI NATARAJAN, RAMA · 2003 to 2021
$7.9M
Epigenetics of Chronic Kidney DiseaseR01DK087635 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATALIN SUSZTAK · 2009 to 2026
$7.0M
Transcriptional Regulation by Angiotensin II in Vascular Smooth Muscle CellsR01HL106089 · NHLBI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NATARAJAN, RAMA · 2011 to 2024
$6.6M
Paternal Contributions to Metabolic Disease in Offspring: Environment, Epigenetics, and SpermR01DK106193 · NIDDK · JOSLIN DIABETES CENTER · PI PATTI, MARY E · 2016 to 2024
$4.3M
Epigenetic drivers and biomarkers of diabetic kidney diseaseDP3DK108220 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SUSZTAK, KATALIN · 2015 to 2015
$2.4M
Epigenetic Markers of Complications and Metabolic Memory in the DCCT/EDIC cohort.DP3DK106917 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NATARAJAN, RAMA · 2015 to 2015
$2.2M
NHLBI NIH HHS R01 HL106089NIDDK NIH HHS DP3 DK106917NIDDK NIH HHS DP3 DK108220NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK065073NIDDK NIH HHS R01 DK087635NIDDK NIH HHS R01 DK106193
6 · The paper itself

Abstract

The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017. International experts in genetics, epigenetics, computational biology, and physiology discussed the current state of understanding of the relationships between genetics, epigenetics, and environment in diabetes and examined existing evidence for the role of epigenetic factors in regulating metabolism and the risk of diabetes and its complications. The authors summarize the presentations, which highlight how the complex interactions between genes and environment may in part be mediated through epigenetic changes and how information about nutritional and other environmental stimuli can be transmitted to the next generation. In addition, the authors present expert consensus on knowledge gaps and research recommendations for the field.

Indexed as

Diabetes MellitusEpigenesis, GeneticEpigenomicsObesityCongresses as TopicDNA MethylationHumans

Identifiers

PMID30237160
PMCPMC6463748

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.