ArticleScientific reports2018
White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis.Journal of affective disorders · 2022Pooled it
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Divergent Myelination or Divergent Trajectories? Insights from MPF Mapping in Bipolar Disorder and Recurrent Depressive Disorder.Bioengineering (Basel, Switzerland) · 2026Article
- Macromolecular Proton Fraction Reveals Divergent White Matter Myelination in Bipolar Disorder and Unipolar Recurrent Depression.Bioengineering (Basel, Switzerland) · 2026Article
- Blood‑brain barrier dysfunction in schizophrenia: Mechanisms and implications (Review).International journal of molecular medicine · 2025Review
- Linking Psychotic-Like Experiences and Brain White Matter Microstructure in Young Women.Brain and behavior · 2025Article
- Quantitative magnetization transfer and g-ratio imaging of white matter myelin in early psychotic spectrum disorders.Molecular psychiatry · 2025Article
- Morphological abnormalities in youth with bipolar disorder and their relationship to clinical characteristics.Journal of affective disorders · 2023Article
- Considerations on brain age predictions from repeatedly sampled data across time.Brain and behavior · 2023Article
- Using Fatty Acid-Binding Proteins as Potential Biomarkers to Discriminate between Parkinson's Disease and Dementia with Lewy Bodies: Exploration of a Novel Technique.International journal of molecular sciences · 2023Article
- Mapping the impact of nonlinear gradient fields with noise on diffusion MRI.Magnetic resonance imaging · 2023Article
- Deviations from normative brain white and gray matter structure are associated with psychopathology in youth.Developmental cognitive neuroscience · 2022Article
- Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication.Translational psychiatry · 2022Article
- Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study.Schizophrenia research. Cognition · 2022Review
- Cardiometabolic risk factors associated with brain age and accelerate brain ageing.Human brain mapping · 2022Article
- Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review.Journal of psychiatry and brain science · 2022Article
- Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults.NeuroImage. Clinical · 2022Article
- Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders.Frontiers in neuroscience · 2022Review
- Automated Multiclass Artifact Detection in Diffusion MRI VolumesFrontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supported by histological and genetic evidence implicating myelin, neuroinflammation and oligodendrocyte dysfunction in schizophrenia spectrum disorders (SZ), diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) abnormalities when compared to healthy controls (HC). The diagnostic specificity remains unclear, with bipolar disorders (BD) frequently conceptualized as a less severe clinical manifestation along a psychotic spectrum. Further, the age-related dynamics and possible sex differences of WM abnormalities in SZ and BD are currently understudied. Using tract-based spatial statistics (TBSS) we compared DTI-based microstructural indices between SZ (n = 128), BD (n = 61), and HC (n = 293). We tested for age-by-group and sex-by-group interactions, computed effect sizes within different age-bins and within genders. TBSS revealed global reductions in fractional anisotropy (FA) and increases in radial (RD) diffusivity in SZ compared to HC, with strongest effects in the body and splenium of the corpus callosum, and lower FA in SZ compared to BD in right inferior longitudinal fasciculus and right inferior fronto-occipital fasciculus, and no significant differences between BD and HC. The results were not strongly dependent on age or sex. Despite lack of significant group-by-age interactions, a sliding-window approach supported widespread WM involvement in SZ with most profound differences in FA from the late 20 s.
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