ReviewCurrent opinion in genetics & development2018
The critical needs and challenges for genetic architecture studies in Africa.
Review in Current opinion in genetics & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- Malaria-Related Host Genetic Variation in an Endemic Population of Southern Senegal.International journal of molecular sciences · 2026Article
- Clinical Utility of Trio Exome Sequencing in Rwandan Children With Autism Spectrum Disorder.Molecular genetics & genomic medicine · 2026Article
- Systemic barriers and opportunities for equity in early implementation of genetic testing and counseling for cardiomyopathies in Tanzania.Communications medicine · 2025Review
- Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci.Nature communications · 2025Article
- Endovascular Treatment for Aortic Diseases: Intercontinental Disparities.Current cardiology reports · 2025Review
- Driving Global Health equity and precision medicine through African genomic data.Human molecular genetics · 2025Article
- Attitudes regarding polygenic risk testing for lung cancer: a mixed-methods study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Refining breast cancer genetic risk and biology through multi-ancestry fine-mapping analyses of 192 risk regions.Nature genetics · 2025Observational
- Genetic Risk of Different Populations in COVID-19 Susceptibility and Severity.Infection and drug resistance · 2025Review
- Methodologies underpinning polygenic risk scores estimation: a comprehensive overview.Human genetics · 2024Review
- Expanding the Russian allele frequency reference via cross-laboratory data integration: insights from 7452 exome samples.National science review · 2024Article
- Aspiring toward equitable benefits from genomic advances to individuals of ancestrally diverse backgrounds.American journal of human genetics · 2024Review
- Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.Nature genetics · 2024Article
- Beyond borders: A commentary on the benefit of promoting immigrant populations in genome-wide association studies.HGG advances · 2023Review
- Performance and accuracy evaluation of reference panels for genotype imputation in sub-Saharan African populations.Cell genomics · 2023Article
- Current status and future directions of amyotrophic lateral sclerosis research in Africa: a perspective.Annals of medicine and surgery (2012) · 2023Article
- Low and differential polygenic score generalizability among African populations due largely to genetic diversity.HGG advances · 2023Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Confronting ethical and social issues related to the genetics of musicality.Annals of the New York Academy of Sciences · 2023Article
- Extensive set of African ancestry-informative markers (AIMs) to study ancestry and population health.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Human genetic studies have long been vastly Eurocentric, raising a key question about the generalizability of these study findings to other populations. Because humans originated in Africa, these populations retain more genetic diversity, and yet individuals of African descent have been tremendously underrepresented in genetic studies. The diversity in Africa affords ample opportunities to improve fine-mapping resolution for associated loci, discover novel genetic associations with phenotypes, build more generalizable genetic risk prediction models, and better understand the genetic architecture of complex traits and diseases subject to varying environmental pressures. Thus, it is both ethically and scientifically imperative that geneticists globally surmount challenges that have limited progress in African genetic studies to date. Additionally, African investigators need to be meaningfully included, as greater inclusivity and enhanced research capacity afford enormous opportunities to accelerate genomic discoveries that translate more effectively to all populations. We review the advantages, challenges, and examples of genetic architecture studies of complex traits and diseases in Africa. For example, with greater genetic diversity comes greater ancestral heterogeneity; this higher level of understudied diversity can yield novel genetic findings, but some methods that assume homogeneous population structure and work well in European populations may work less well in the presence of greater heterogeneity in African populations. Consequently, we advocate for methodological development that will accelerate studies important for all populations, especially those currently underrepresented in genetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.