Evidence map›Paper›PMID 30249601›Full record

ReviewCold Spring Harbor perspectives in medicine2019

Electromagnetic Regulation of Cell Activity.

Sarah A Stanley, Jeffrey M Friedman

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sarah A StanleyDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Jeffrey M FriedmanLaboratory of Molecular Genetics, Rockefeller University, New York, New York 10065.
Howard Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Remote Electromagnetic Control of Neural Activity for Treatment of Parkinson's DiseaseR01NS097184 · NINDS · ROCKEFELLER UNIVERSITY · PI DORDICK, JONATHAN S., FRIEDMAN, JEFFREY M · 2016 to 2020
$3.4M
Remote regulation of neural activityU01MH105941 · NIMH · ROCKEFELLER UNIVERSITY · PI STANLEY, SARAH AMY · 2014 to 2016
$1.2M
Remote Modulation of the Peripheral Nervous SystemOT2OD024912 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STANLEY, SARAH AMY · 2017 to 2019
$1.1M
NIDDK NIH HHS P30 DK020541NIH HHS OT2 OD024912NIMH NIH HHS U01 MH105941NINDS NIH HHS R01 NS097184
6 · The paper itself

Abstract

The ability to observe the effects of rapidly and reversibly regulating cell activity in targeted cell populations has provided numerous physiologic insights. Over the last decade, a wide range of technologies have emerged for regulating cellular activity using optical, chemical, and, more recently, electromagnetic modalities. Electromagnetic fields can freely penetrate cells and tissue and their energy can be absorbed by metal particles. When released, the absorbed energy can in turn gate endogenous or engineered receptors and ion channels to regulate cell activity. In this manner, electromagnetic fields acting on external nanoparticles have been used to exert mechanical forces on cell membranes and organelles to generate heat and interact with thermally activated proteins or to induce receptor aggregation and intracellular signaling. More recently, technologies using genetically encoded nanoparticles composed of the iron storage protein, ferritin, have been used for targeted, temporal control of cell activity in vitro and in vivo. These tools provide a means for noninvasively modulating gene expression, intracellular organelles, such as endosomes, and whole-cell activity both in vitro and in freely moving animals. The use of magnetic fields interacting with external or genetically encoded nanoparticles thus provides a rapid noninvasive means for regulating cell activity.

Indexed as

Cell Physiological PhenomenaElectromagnetic FieldsMagnetite NanoparticlesAnimalsGene Expression RegulationHumansSignal TransductionStress, MechanicalMagnetite Nanoparticles

Identifiers

PMID30249601
PMCPMC6496334
OpenAlexW2894419386

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.