Evidence map›Paper›PMID 30252533›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Urinary concentrating defect in mice lacking Epac1 or Epac2.

Alena Cherezova, Viktor Tomilin, Vadym Buncha, Oleg Zaika, Pablo A Ortiz, Fang Mei, Xiaodong Cheng, Mykola Mamenko, Oleh Pochynyuk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. A peek into Epac physiology in the kidney.American journal of physiology. Renal physiology · 2019
    Article
  9. TRPV4 deletion protects against hypokalemia during systemic KAmerican journal of physiology. Renal physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alena CherezovaDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Viktor TomilinDepartment of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Vadym BunchaDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Oleg ZaikaDepartment of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Pablo A OrtizHypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA; and.
Fang MeiDepartment of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Xiaodong ChengDepartment of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Mykola MamenkoDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Oleh PochynyukDepartment of Integrative Biology and Pharmacology The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Funding

Epac/cAMP-GEF, A Novel Intracellular cAMP ReceptorR01GM066170 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CHENG, XIAODONG · 2003 to 2017
$4.6M
Fructose induced salt-sensitive hypertension: Role of thick ascending limb transportR01DK107263 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ORTIZ, PABLO A. · 2016 to 2020
$2.1M
Exchange Protein directly Activated by cAMP (EPAC): Structure, Function and TherapeuticsR35GM122536 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHENG, XIAODONG · 2017 to 2021
$1.9M
Regulation of K+ balance by distal nephron TRPV4 channelR01DK119170 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2018 to 2022
$1.7M
Aldosterone-independent regulation of ENaC by systemic saltR01DK095029 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095029NIDDK NIH HHS R01 DK107263NIDDK NIH HHS R01 DK119170NIGMS NIH HHS R01 GM066170NIGMS NIH HHS R35 GM122536
6 · The paper itself

Abstract

cAMP is a universal second messenger regulating a plethora of processes in the kidney. Two downstream effectors of cAMP are PKA and exchange protein directly activated by cAMP (Epac), which, unlike PKA, is often linked to elevation of [Ca

Indexed as

AnimalsAquaporin 2Arginine VasopressinCalcium SignalingDiuresisGene DeletionGuanine Nucleotide Exchange FactorsKidneyKidney Concentrating AbilityMiceMice, KnockoutOsmosisPolyuriaSodium-Hydrogen Exchanger 3Aqp2 protein, mouseAquaporin 2Arginine VasopressinEpac protein, mouseGuanine Nucleotide Exchange FactorsRapgef4 protein, mouseSlc9a3 protein, mouseSodium-Hydrogen Exchanger 3AQP2collecting ductNHE-3ureawater deprivation

Identifiers

PMID30252533
PMCPMC6338637

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.