ArticleJournal of psychopharmacology (Oxford, England)2018
Anhedonia and depression severity dissociated by dmPFC resting-state functional connectivity in adolescents.
Article in Journal of psychopharmacology (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Abnormal resting-state functional connectivity in anhedonia: A systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Multilevel growth curve analyses of behavioral activation for anhedonia (BATA) and mindfulness-based cognitive therapy effects on anhedonia and resting-state functional connectivity: Interim results of a randomized trialJournal of affective disorders · 2021Trial
- Symptom-specific links between internalizing problems and functional connectivity in adolescents: a network analysis.European child & adolescent psychiatry · 2026Article
- Functional Breakdown of Temporoparietal Junction Interaction in High-depression Individuals: Evidence from Multi-Metric Connectomics.Brain structure & function · 2026Article
- A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use.JAACAP open · 2025Review
- Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depression.bioRxiv : the preprint server for biology · 2025Article
- Default mode network static-dynamic functional signatures in first-episode drug-naive major depressive disorder.Comprehensive psychoneuroendocrinology · 2025Article
- Disruption of Multimodal Brain Networks and Structural-Functional Coupling in Adolescents with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- Individualized identification value of stress-related network structural-functional properties and HPA axis reactivity for subthreshold depression.Translational psychiatry · 2024Article
- Frontal pole-precuneus connectivity is associated with a discrepancy between self-rated and observer-rated depression severity in mood disorders: a resting-state functional magnetic resonance imaging study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neural substrates of predicting anhedonia symptoms in major depressive disorder via connectome-based modeling.CNS neuroscience & therapeutics · 2024Article
- Vulnerable brain regions in adolescent major depressive disorder: A resting-state functional magnetic resonance imaging activation likelihood estimation meta-analysis.World journal of psychiatry · 2024Article
- Metabolic Covariance Connectivity of Posterior Cingulate Cortex Associated with Depression Symptomatology Level in Healthy Young Adults.Metabolites · 2023Article
- Altered functional connectivity density and structural covariance networks in women with premenstrual syndrome.Quantitative imaging in medicine and surgery · 2023Article
- A feasibility study of goal-directed network-based real-time fMRI neurofeedback for anhedonic depression.Frontiers in psychiatry · 2023Article
- Associations between resting state functional brain connectivity and childhood anhedonia: A reproduction and replication study.PloS one · 2023Article
- Differential Impact of Anxious Misery Psychopathology on Multiple Representations of the Functional Connectome.Biological psychiatry global open science · 2022Article
- Sleep to Internalizing Pathway in Young Adolescents (SIPYA): A proposed neurodevelopmental model.Neuroscience and biobehavioral reviews · 2022Review
- Change of Circulating Vascular Endothelial Growth Factor Level and Reduction of Anhedonia Are Associated in Patients With Major Depressive Disorder Treated With Repetitive Transcranial Magnetic Stimulation.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionGiven the heterogeneity within depression, in this study we aim to examine how resting-state functional connectivity (RSFC) in adolescents is related to anhedonia and depression severity on a continuum in line with the research domain criteria (RDoC) approach.
methodsWe examined how RSFC in the dorsal medial prefrontal cortex (dmPFC), nucleus accumbens (NAcc) and pregenual anterior cingulate cortex (pgACC) was related to anhedonia and depression severity in 86 adolescents (13-21 years).
resultsWe found both anhedonia and depression severity related to decreased dmPFC RSFC with the precuneus, a part of the default mode network. However we also found that increased dmPFC connectivity with the ACC/paracingulate gyrus related to anhedonia whereas increased RSFC with the frontal pole related to depression severity. DISCUSSION: This work extends the view that the dmPFC is a potential therapeutic target for depression in two ways: 1. We report dmPFC connectivity in adolescents; and 2. We show different dmPFC RSFC specific to anhedonia and depression severity, providing neural targets for intervention in young people at risk of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.