Evidence map›Paper›PMID 30273693›Full record

ArticlePeptides2019

PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.

Terry W Moody, Lingaku Lee, Tatiana Iordanskaia, Irene Ramos-Alvarez, Paola Moreno, Howard E Boudreau, Thomas L Leto, Robert T Jensen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Peptides, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024
    Review
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Terry W MoodyDepartment of Health and Human Services, National Institutes of Health, National Cancer Institute, Center for Cancer Research, 9609 Medical Center Drive, Room 2W-340, Bethesda, MD, 20892, USA. Electronic address: moodyt@mail.nih.gov.
Lingaku LeeNational Institute of Diabetes, Digestive and Kidney Disease, Digestive Diseases Branch, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
Tatiana IordanskaiaNational Institute of Diabetes, Digestive and Kidney Disease, Digestive Diseases Branch, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
Irene Ramos-AlvarezNational Institute of Diabetes, Digestive and Kidney Disease, Digestive Diseases Branch, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
Paola MorenoNational Institute of Diabetes, Digestive and Kidney Disease, Digestive Diseases Branch, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
Howard E BoudreauNational Institute of Allergy and Infectious Diseases, Lab. Host Defenses, 12441 Parklawn Dr., Rockville, MD, 20852, USA.
Thomas L LetoNational Institute of Allergy and Infectious Diseases, Lab. Host Defenses, 12441 Parklawn Dr., Rockville, MD, 20852, USA.
Robert T JensenNational Institute of Diabetes, Digestive and Kidney Disease, Digestive Diseases Branch, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
National Institute of Diabetes and Digestive and Kidney Diseases · USNational Institute of Allergy and Infectious Diseases · USCenter for Cancer Research · US

Funding

NOX family NADPH oxidases: roles in innate immunity and inflammatory diseaseZIAAI000614 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LETO, THOMAS · 2009 to 2024
$16.2M
Diagnosis, Natural History, Management,tumor biology of Gastrinomas/PETs/Neuroendocrine tumorsZIADK053200 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JENSEN, ROBERT · 2009 to 2025
$4.3M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS Z99 DK999999Intramural NIH HHS ZIA DK053200
6 · The paper itself

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) is a growth factor for lung cancer cells. PACAP-27 or PACAP-38 binds with high affinity to non-small cell lung cancer (NSCLC) cells, causing elevated cytosolic Ca

Indexed as

Gene Expression Regulation, NeoplasticTranscriptional ActivationCarcinoma, Non-Small-Cell LungCell Line, TumorDual Specificity Phosphatase 2HumansLung NeoplasmsNeoplasm ProteinsReactive Oxygen SpeciesDual Specificity Phosphatase 2Neoplasm ProteinsReactive Oxygen SpeciesDuoxEGFRERKHER2Lung cancerNoxPAC1ROSTransactivation

Identifiers

PMID30273693
PMCPMC6438776
OpenAlexW2893264060

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.