Evidence map›Paper›PMID 30275014›Full record

ArticleThe Journal of biological chemistry2018

The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis.

Chong Shen, Yinghui Liu, Haijia Yu, Daniel R Gulbranson, Igor Kogut, Ganna Bilousova, Chen Zhang, Michael H B Stowell, Jingshi Shen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023
    Article
  4. Review
  5. The function of VAMP2 in mediating membrane fusion: An overview.Frontiers in molecular neuroscience · 2022
    Review
  6. Article
  7. Chaperoning SNARE Folding and Assembly.Annual review of biochemistry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Chong ShenFrom the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309.
Yinghui LiuFrom the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309,; the Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Haijia YuFrom the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309,; the Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China,. Electronic address: haijiayu@gmail.com.
Daniel R GulbransonFrom the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309.
Igor Kogutthe Department of Dermatology and Charles C. Gates Center for Regenerative Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, and.
Ganna Bilousovathe Department of Dermatology and Charles C. Gates Center for Regenerative Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, and.
Chen Zhangthe School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Michael H B StowellFrom the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309.
Jingshi ShenFrom the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309,. Electronic address: jingshi.shen@colorado.edu.
University of Colorado Boulder · USNanjing Normal University · CNCapital Medical University · CNGates (United States) · USUniversity of Colorado Denver · US

Funding

Protein-membrane interactions in regulated exocytosisR35GM126960 · NIGMS · UNIVERSITY OF COLORADO · PI Jingshi Shen · 2018 to 2026
$3.2M
Identifying exosome-mediated cargo transport machinery in Alzheimer's diseaseRF1AG061829 · NIA · UNIVERSITY OF COLORADO · PI SHEN, JINGSHI, STOWELL, MICHAEL H. B. · 2018 to 2018
$2.7M
Regulatory Mechanisms of GLUT4 ExocytosisR01DK095367 · NIDDK · UNIVERSITY OF COLORADO · PI SHEN, JINGSHI · 2013 to 2017
$1.7M
Regulatory Mechanisms of GLUT4 ExocytosisR56DK095367 · NIDDK · UNIVERSITY OF COLORADO · PI SHEN, JINGSHI · 2012 to 2018
$598k
NIA NIH HHS RF1 AG061829NIDDK NIH HHS R01 DK095367NIDDK NIH HHS R56 DK095367NIGMS NIH HHS R35 GM126960
6 · The paper itself

Abstract

Sec1/Munc18 (SM) proteins promote intracellular vesicle fusion by binding to

Indexed as

ExocytosisAmino Acid MotifsHumansMunc18 ProteinsNeuronsPeptidesProtein BindingProtein TransportSignal TransductionSynapsesSynaptic TransmissionSyntaxin 1Munc18 ProteinsPeptidesSyntaxin 1exocytosismembrane functionmembrane fusionmembrane proteinsmembrane reconstitutionMunc18N-peptideorganelleSM proteinSNARE proteinssynaptic transmissionvesicle transport

Identifiers

PMID30275014
PMCPMC6254354
OpenAlexW2895451077

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.