Evidence map›Paper›PMID 30276717›Full record

ArticleNeurotoxicity research2019

Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols.

Karla P Melo, Carolliny M Silva, Michael F Almeida, Rodrigo S Chaves, Tania Marcourakis, Sandra M Cardoso, Marilene Demasi, Luis E S Netto, Merari F R Ferrari

Open access · greenAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Karla P MeloDepartamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, Cidade Universitaria, Sao Paulo, SP, 05508-090, Brazil.
Carolliny M SilvaDepartamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, Cidade Universitaria, Sao Paulo, SP, 05508-090, Brazil.
Michael F AlmeidaDepartamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, Cidade Universitaria, Sao Paulo, SP, 05508-090, Brazil.
Rodrigo S ChavesDepartamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, Cidade Universitaria, Sao Paulo, SP, 05508-090, Brazil.
Tania MarcourakisDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Sandra M CardosoCenter for Neuroscience and Cell Biology and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Marilene DemasiLaboratorio de Bioquimica e Biofisica, Instituto Butantan, Sao Paulo, SP, Brazil.
Luis E S NettoDepartamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, Cidade Universitaria, Sao Paulo, SP, 05508-090, Brazil.
Merari F R FerrariDepartamento de Genetica e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, Cidade Universitaria, Sao Paulo, SP, 05508-090, Brazil. merari@usp.br.
Universidade de São Paulo · BRInstituto Butantan · BRUniversity of Coimbra · PT

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 471999/2013-0; 401670/2013-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/00478-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/06434-7; 2013/08028-1; 2015/18961- 2Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/15281-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/15283-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/14273-0
6 · The paper itself

Abstract

Proteostasis and oxidative stress were evaluated in motor cortex and spinal cord of aged Lewis rats exposed to 1 mg/kg/day of rotenone during 4 or 8 weeks, prior or after practicing three protocols of mild treadmill running. Results demonstrated that exercise done after the beginning of neurodegeneration reverted the increased oxidative stress (measured by H

Indexed as

AnimalsExercise TestInsecticidesMaleMotor CortexNerve DegenerationOxidative StressPhysical Conditioning, AnimalProteostasisRatsRats, Inbred LewRotenoneInsecticidesRotenoneAutophagyMotor cortexPhysical exerciseProteasomeRotenoneSpinal cord

Identifiers

PMID30276717
OpenAlexW2895443225

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.