Evidence map›Paper›PMID 30279397›Full record

Trial reportNutrients2018

Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults.

Peter R C Howe, Hamish M Evans, Julia C Kuszewski, Rachel H X Wong

Erratum issuedOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Peter R C HoweSchool of Biomedical Sciences and Pharmacy, Clinical Nutrition Research Centre, University of Newcastle, Callaghan, NSW 2308, Australia. peter.howe@newcastle.edu.au.ORCID 0000-0001-6546-7742
Hamish M EvansSchool of Biomedical Sciences and Pharmacy, Clinical Nutrition Research Centre, University of Newcastle, Callaghan, NSW 2308, Australia. hamish.evans@newcastle.edu.au.
Julia C KuszewskiSchool of Biomedical Sciences and Pharmacy, Clinical Nutrition Research Centre, University of Newcastle, Callaghan, NSW 2308, Australia. Julia.kuszewski@uon.edu.au.ORCID 0000-0001-5718-0258
Rachel H X WongSchool of Biomedical Sciences and Pharmacy, Clinical Nutrition Research Centre, University of Newcastle, Callaghan, NSW 2308, Australia. rachel.wong@newcastle.edu.au.ORCID 0000-0002-6550-5646
University of Newcastle Australia · AUUniversity of Southern Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purported benefits of long chain omega-3 polyunsaturated fatty acid (LCn-3PUFA) for brain function may be attributable, at least in part, to improved cerebral perfusion. A pilot randomised controlled trial was undertaken to investigate effects of taking a DHA-rich fish oil supplement for 20 weeks on cerebrovascular function, mood and cognitive performance. Borderline hypertensives aged 40⁻85 years with low habitual LCn-3PUFA intake took four capsules/day of EPAX (1600 mg DHA + 400 mg EPA) or placebo (corn oil). Cerebrovascular function was assessed at baseline and after 20 weeks in 38 completers (19 on each supplement) using transcranial Doppler ultrasound of blood flow in the middle cerebral artery at rest and whilst performing a battery of cognitive tasks (neurovascular coupling). The primary outcome, cerebrovascular responsiveness (CVR) to hypercapnia, increased 26% (

Indexed as

Dietary SupplementsAdultAffectAgedAged, 80 and overBrainCerebrovascular CirculationCognitionDouble-Blind MethodFatty Acids, Omega-3FemaleHumansHypertensionMaleMiddle AgedSex FactorsFatty Acids, Omega-3cerebral blood flowcerebrovascular functioncognitionhypertensionmoodomega-3

Identifiers

PMID30279397
PMCPMC6213246
OpenAlexW2895113238

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.