Evidence map›Paper›PMID 30284136›Full record

ReviewDigestive diseases and sciences2019

Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells.

Siqing Feng, Qiongqiong Wei, Qing Hu, Xiaomei Huang, Xi Zhou, Gang Luo, Mingming Deng, Muhan Lü

Abstract readReview
PubMed Publisher
In one paragraph

Review in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Piezo channels in the intestinal tract.Frontiers in physiology · 2024
    Review
  10. Review
  11. Article
  12. Is there a correlation between the initial calcium level and Balthazar classification in patients with acute pancreatitis?Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Siqing FengSouthwest Medical University, Zhongshan Street, Jiangyang District, Luzhou, 64600, Sichuan, China.
Qiongqiong WeiSouthwest Medical University, Zhongshan Street, Jiangyang District, Luzhou, 64600, Sichuan, China.
Qing HuDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, 64600, Sichuan, China.
Xiaomei HuangSouthwest Medical University, Zhongshan Street, Jiangyang District, Luzhou, 64600, Sichuan, China.
Xi ZhouDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, 64600, Sichuan, China.
Gang LuoDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, 64600, Sichuan, China.
Mingming DengDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, 64600, Sichuan, China. 793070544@qq.com.
Muhan LüDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, 64600, Sichuan, China. 52721759@qq.com.
Affiliated Hospital of Southwest Medical University · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early pathogenesis of the disease. To clarify the mechanism of maintaining calcium homeostasis in the cell and pathological processes caused by calcium overload would help to research directly targeted therapeutic agents. We will specifically review the following: intracellular calcium homeostasis and regulation, the occurrence of calcium overload in acinar cells, the role of calcium overload in the pathogenesis of AP, the treatment strategy proposed for calcium overload.

Indexed as

Calcium SignalingAcinar CellsAcute DiseaseAnimalsBiomedical ResearchCalciumHomeostasisHumansPancreasPancreatitisRisk FactorsCalciumAcinar cellsCalciumPancreatitisPathophysiologyTherapy

Identifiers

PMID30284136
OpenAlexW2895737365

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.