SynthesisHuman brain mapping2019
White matter microstructure in fetal alcohol spectrum disorders: A systematic review of diffusion tensor imaging studies.
Synthesis in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Cerebellar Microstructural Abnormalities in Obsessive-Compulsive Disorder (OCD): a Systematic Review of Diffusion Tensor Imaging Studies.Cerebellum (London, England) · 2024Pooled it
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- Brain microstructural abnormalities in patients with Wilson's disease: A systematic review of diffusion tenor imaging studies.Brain imaging and behavior · 2022Pooled it
- Effects of Prenatal Methamphetamine Exposure on the Developing Human Brain: A Systematic Review of Neuroimaging Studies.ACS chemical neuroscience · 2021Pooled it
- White matter microstructure in fetal alcohol spectrum disorders: A systematic review of diffusion tensor imaging studies.Human brain mapping · 2019Pooled it
- Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.Journal of neurodevelopmental disorders · 2022Trial
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Developmental Neurotoxicity of Alcohol from Neuronal Basis to Behavioural Outcomes: A Comprehensive Review.Neurology international · 2026Review
- Associations between white matter micro- and macro-structure and attention in 6-7-year-old children with low to moderate prenatal alcohol exposure.Brain imaging and behavior · 2026Article
- Regional cerebellum volume anomalies and associated cognitive function in children with fetal alcohol spectrum disorders.Alcohol, clinical & experimental research · 2026Article
- Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model.Developmental neuroscience · 2025Article
- Decreased Cerebral Blood Flow in Young Children With Prenatal Alcohol Exposure.Biological psychiatry global open science · 2025Article
- Diffusion tensor imaging assessments to investigate motor impairment recovery after minor basal ganglia hemorrhage post-stereotactic surgery.Frontiers in neuroscience · 2025Article
- The Effects of Prenatal Alcohol Exposure on Structural Brain Connectivity and Early Language Skills in a South African Birth Cohort.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Prenatal Alcohol Exposure and Metabolic Disorders in Pediatrics: The Role of the Oxidative Stress-A Review of the Literature.Children (Basel, Switzerland) · 2024Review
- Perinatal influences on academic achievement and the developing brain: a scoping systematic review.Frontiers in psychology · 2024Article
- Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023Review
- Mapping corpus callosum surface reduction in fetal alcohol spectrum disorders with sulci and connectivity-based parcellation.Frontiers in neuroscience · 2023Article
- Atypical developmental trajectories of white matter microstructure in prenatal alcohol exposure: Preliminary evidence from neurite orientation dispersion and density imaging.Frontiers in neuroscience · 2023Article
- High-resolution imaging in studies of alcohol effect on prenatal development.Advances in drug and alcohol research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffusion tensor imaging (DTI) has revolutionized our understanding of the neural underpinnings of alcohol teratogenesis. This technique can detect alterations in white matter in neurodevelopmental disorders, such as fetal alcohol spectrum disorder (FASD). Using Prisma guidelines, we identified 23 DTI studies conducted on individuals with prenatal alcohol exposure (PAE). These studies confirm the widespread nature of brain damage in PAE by reporting diffusivity alterations in commissural, association, and projection fibers; and in relation to increasing cognitive impairment. Reduced integrity in terms of lower fractional anisotropy (FA) and higher mean diffusivity (MD) and radial diffusivity (RD) is reported more consistently in the corpus callosum, cerebellar peduncles, cingulum, and longitudinal fasciculi connecting frontal and temporoparietal regions. Although these interesting results provide insight into FASD neuropathology, it is important to investigate the clinical diversity of this disorder for better treatment options and prediction of progression. The aim of this review is to provide a summary of different patterns of neural structure between PAE and typically developed individuals. We further discuss the association of alterations in diffusivity with demographic features and symptomatology of PAE. With the accumulated knowledge of the neural correlates of FASD presenting symptoms, a comprehensive understanding of the heterogeneity in FASD will potentially improve the disease management and will highlight the diagnostic challenges and potential areas of future research avenues, where neural markers may be beneficial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.