Evidence map›Paper›PMID 30290846›Full record

ArticleBMC research notes2018

A conditional Pax6 depletion study with no morphological effect on the adult mouse corneal epithelium.

Natalie J Dorà, Martine Manuel, Dirk-Jan Kleinjan, David J Price, J Martin Collinson, Robert E Hill, John D West

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Natalie J DoràCentre for Integrative Physiology, Biomedical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Martine ManuelCentre for Discovery Brain Sciences, Biomedical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Dirk-Jan KleinjanMedical and Developmental Genetics Section, MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
David J PriceCentre for Discovery Brain Sciences, Biomedical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
J Martin CollinsonSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
Robert E HillMedical and Developmental Genetics Section, MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
John D WestCentre for Integrative Physiology, Clinical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. John.West@ed.ac.uk.ORCID http://orcid.org/0000-0002-5886-0359
University of Edinburgh · GBWestern General Hospital · GBUniversity of Aberdeen · GB

Funding

Medical Research Council MC_U127584494Medical Research Council MC_UU_00007/8Wellcome TrustWellcome Trust 088876/Z/09/Z
6 · The paper itself

Abstract

objectiveThe corneas of heterozygous Pax6

resultsIn a preliminary study, ubiquitous depletion of Pax6 by tamoxifen treatment of E9.5 CAG-CreER

Indexed as

Age FactorsAnimalsCorneal DiseasesEpithelium, CornealFemaleMaleMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicPAX6 Transcription FactorPax6 protein, mousePAX6 Transcription FactorCAG-CreERCorneaCorneal epitheliumCre-loxPKrt19-CreERMosaic transgene expressionMousePax6

Identifiers

PMID30290846
PMCPMC6173925
OpenAlexW2895483452

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.