Evidence map›Paper›PMID 30295289›Full record

ArticleeLife2018

Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota.

Kathryn Eaton, Ali Pirani, Evan S Snitkin, Reproducibility Project: Cancer Biology

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Kathryn EatonDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Ali PiraniDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Evan S SnitkinDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, United States.
Reproducibility Project: Cancer Biology
Center for Open Science · USScience Exchange (United States) · USUniversity of Michigan · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
NIDDK NIH HHS P30 DK034987NIH HHS P40 OD010995
6 · The paper itself

Abstract

As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Eaton et al., 2015) that described how we intended to replicate selected experiments from the paper "Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota" (Arthur et al., 2012). Here we report the results. We observed no impact on bacterial growth or colonization capacity when the polyketide synthase (

Indexed as

AnimalsCarcinogenesisCell Line, TumorDNA DamageEscherichia coliGastrointestinal MicrobiomeHumansInflammationInterleukin-10IntestinesMiceNeoplasm InvasivenessNeoplasmsPolyketide SynthasesXenograft Model Antitumor AssaysInterleukin-10Polyketide Synthasescancer biologyE. coliIntestinal InflammationmetasciencemicrobiotamousereplicationreproducibilityReproducibility Project: Cancer Biology

Identifiers

PMID30295289
PMCPMC6175580
OpenAlexW2895497083

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.