Evidence map›Paper›PMID 30301136›Full record

ArticleInternational journal of molecular sciences2018

Paired CRISPR/Cas9 Nickases Mediate Efficient Site-Specific Integration of

Yanchi Wang, Junya Zhao, Nannan Duan, Wei Liu, Yuxuan Zhang, Miaojin Zhou, Zhiqing Hu, Mai Feng, Xionghao Liu, Lingqian Wu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. CRISPR-Mediated In Situ Introduction or Integration ofInternational journal of molecular sciences · 2023
    Article
  6. Article
  7. Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yanchi WangCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. wangyanchi@sklmg.edu.cn.ORCID 0000-0002-9783-9544
Junya ZhaoCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. zhaojunya@sklmg.edu.cn.
Nannan DuanCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. duannannan@sklmg.edu.cn.
Wei LiuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. liuwei@sklmg.edu.cn.
Yuxuan ZhangCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. zhangyuxuan@sklmg.edu.cn.
Miaojin ZhouCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. zhoumiaojin@sklmg.edu.cn.ORCID 0000-0002-6636-6000
Zhiqing HuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. huzhiqing@sklmg.edu.cn.
Mai FengCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. fengmai@sklmg.edu.cn.
Xionghao LiuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. liuxionghao@sklmg.edu.cn.
Lingqian WuCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. wulingqian@sklmg.edu.cn.
Zhuo LiCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. lizhuo@sklmg.edu.cn.
Desheng LiangCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China. liangdesheng@sklmg.edu.cn.
Central South University · CN

Funding

National Key Research and Development Program of China 2016YFC0905100National Natural Science Foundation of China 81470299National Natural Science Foundation of China 81770200
6 · The paper itself

Abstract

Hemophilia B (HB) is an X-linked recessive bleeding disorder, caused by

Indexed as

AnimalsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated Protein 9Deoxyribonuclease IDNA, RibosomalFactor IXGene TargetingGenetic LociHemophilia BHepatocytesHumansMiceMice, SCIDMouse Embryonic Stem CellsCRISPR-Associated Protein 9Deoxyribonuclease IDNA, RibosomalFactor IXCRISPR/Cas9 nickasegene targetinggene therapyHemophilia Bhepatic progenitor like cellsintrasplenic transplantationmESCsribosomal DNA

Identifiers

PMID30301136
PMCPMC6213315
OpenAlexW2895482409

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.