Evidence mapPaperPMID 30333575Full record

ArticleScientific reports2018

Oral formulation of DPP-4 inhibitor plus Quercetin improves metabolic homeostasis in type 1 diabetic rats.

Pedro Henrique de A Miranda, Kissyla Christine Duarte Lacerda, Carolina Morais Araújo, José Mario Barichello, Wanderson Geraldo Lima, Daniela Caldeira Costa

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pedro Henrique de A MirandaLaboratório de Bioquímica Metabólica (LBM), Departamento de Ciências Biológicas (DECBI), Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
Kissyla Christine Duarte LacerdaPrograma de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
Carolina Morais AraújoPrograma de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
José Mario BarichelloEscola de Farmácia, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
Wanderson Geraldo LimaPrograma de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil.
Daniela Caldeira CostaLaboratório de Bioquímica Metabólica (LBM), Departamento de Ciências Biológicas (DECBI), Universidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, 35400-000, Brazil. dani.caldeiracosta@gmail.com.ORCID http://orcid.org/0000-0001-8904-332X
Universidade Federal de Ouro Preto · BR

Funding

Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 454472/2014-5
6 · The paper itself

Abstract

This study aimed to investigate the potential of an oral formulation (QV formulation) containing Quercetin and a Dipeptidyl Peptidase-4 Inhibitor (DPP-4 inhibitor), Vildagliptin, in improving metabolic homeostasis in type 1 diabetes model. Female albino Fischer rats were divided into four groups: untreated control animals (C), untreated diabetic animals (D), diabetic animals treated with QV formulation (DQV), and diabetic animals treated with insulin (DI). Diabetes was induced by injection of alloxan (135 mg kg body mass)

Indexed as

Administration, OralAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Dipeptidyl-Peptidase IV InhibitorsDrug Therapy, CombinationFemaleHomeostasisInsulinLipidsQuercetinRats, Inbred F344Time FactorsVildagliptinBlood GlucoseDipeptidyl-Peptidase IV InhibitorsInsulinLipidsQuercetinVildagliptin

Identifiers

PMID30333575
PMCPMC6192983
OpenAlexW2897150436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.