ReviewCirculation research2018
Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk.
Review in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06345118 (Evaluate the Results of Fall Prevention in Older Adults With Type 2 Diabetes Mellitus), which is not on this map. Cited by 242 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluate the Results of Fall Prevention in Older Adults With Type 2 Diabetes Mellitus
Who cites it
242 citing papers in PubMed, 4 syntheses or guidelines pooled it, 426 citations in OpenAlex.
- Association Between the Magnitude of Glycemic Control and Body Weight Loss With GLP-1 Receptor Agonists and Risk of Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-analyses of Randomized Diabetes Cardiovascular Outcomes Trials.Cardiovascular drugs and therapy · 2025Pooled it
- Pooled it
- Effects of aquatic exercise on improving body composition and muscle strength in the older adults: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population.Diabetes & metabolism journal · 2023Pooled it
- Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High-Fat Meals.Molecular nutrition & food research · 2026Trial
- Effect of Creatine Monohydrate Supplementation on Macro- and Microvascular Endothelial Function in Older Adults: A Pilot Study.Nutrients · 2024Trial
- Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomised placebo-controlled trial.The lancet. Diabetes & endocrinology · 2024Trial
- Effects of Twenty-Four Weeks of Resistance Exercise Training on Body Composition, Bone Mineral Density, Functional Fitness and Isokinetic Muscle Strength in Obese Older Women: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Article
- Aging Affects Pancreatic α-Cell Function and Promotes Hyperglucagonemia: Implications in Age-Associated Diabetes.Aging cell · 2026Article
- Glycemic status-dependent proteomic signatures of biological aging for health risk prediction.GeroScience · 2026Article
- Metabolic Profiling of Epigenetic Aging and Its Associations With Aging-Related Phenotypes and Modifiable Lifestyle Factors.Aging cell · 2026Article
- Blood pressure variability and frailty: mechanisms, evidence, and clinical implications.International urology and nephrology · 2026Review
- Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.Nature aging · 2026Article
- Projections of diabetes mellitus in Japan through 2040: a bayesian age-period-cohort analysis of the national health and nutrition survey population.The Lancet regional health. Western Pacific · 2026Article
- Influence of age on the development of stress hyperglycemia during first-onset ST-elevation myocardial infarction.Journal of diabetes investigation · 2026Article
- The coordinated actions of metformin in the intestine and liver improves hyperglycemia.Cell reports · 2026Article
- Article
- Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3.Nature communications · 2026Article
- The moderating role of central adiposity, sex and age, on the association between animal- and plant-based protein intake and the 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002-2022).European journal of nutrition · 2026Article
182 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD). During the past 50 years, there has been an dramatic increase in life expectancy with a simultaneous increase in the prevalence of diabetes mellitus in the older population. This large number of older individuals with diabetes mellitus is problematic given that CVD risk associated with aging and diabetes mellitus. In this review, we summarize epidemiological data relating to diabetes mellitus and CVD, with an emphasis on the aging population. We then present data on hyperglycemia as a risk factor for CVD and review the current knowledge of age-related changes in glucose metabolism. Next, we review the role of obesity in the pathogenesis of age-related glucose dysregulation, followed by a summary of the results from major randomized controlled trials that focus on cardiovascular risk reduction through glycemic control, with a special emphasis on older adults. We then conclude with our proposed model of aging that body composition changes and insulin resistance link possible dysregulation of physiological pathways leading to obesity and diabetes mellitus-both forms of accelerated aging-and risks for CVD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.