ReviewPediatric research2019
Early behavioral indices of inherited liability to autism.
Review in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Filled Pause Use in Autistic Adults and Their First-Degree Relatives: Gender Differences and Within-Family Associations.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Using the Infant Sibling-Design to Explore Associations Between Autism and ADHD Traits in Probands and Temperament in the Younger Siblings.Journal of autism and developmental disorders · 2024Article
- Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment.Frontiers in psychiatry · 2023Article
- Social Deficits or Interactional Differences? Interrogating Perspectives on Social Functioning in Autism.Frontiers in psychiatry · 2022Article
- Clinical and Translational Implications of an Emerging Developmental Substructure for Autism.Annual review of clinical psychology · 2021Article
- New guidance to seekers of autism biomarkers: an update from studies of identical twins.Molecular autism · 2021Article
- A Unifying Theory for Autism: The Pathogenetic Triad as a Theoretical Framework.Frontiers in psychiatry · 2021Article
- Brain function distinguishes female carriers and non-carriers of familial risk for autism.Molecular autism · 2020Article
- Genetic architecture of reciprocal social behavior in toddlers: Implications for heterogeneity in the early origins of autism spectrum disorder.Development and psychopathology · 2020Article
- On the Nature of Monozygotic Twin Concordance and Discordance for Autistic Trait Severity: A Quantitative Analysis.Behavior genetics · 2020Article
- Quantitative trait variation in ASD probands and toddler sibling outcomes at 24 months.Journal of neurodevelopmental disorders · 2020Article
- The Neurodevelopment of Autism from Infancy Through Toddlerhood.Neuroimaging clinics of North America · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
objectiveThe observed heterogeneity of autism spectrum disorder (ASD)-and the diversity of rare germline mutations with which it has been associated-has been difficult to reconcile with knowledge of its pronounced heritability in the population.
methodsThis article reviews and synthesizes recent family and developmental studies incorporating behavioral indices of inherited risk for ASD.
resultsAutism may arise from critical combinations of early inherited neurobehavioral susceptibilities-some specific to autism, some not-each of which may be traceable to partially-independent sets of genetic variation. These susceptibilities and their respective genetic origins may not relate to the characterizing symptoms of autism (after it develops) in a straightforward way, and may account for "missing heritability" in molecular genetic studies.
conclusionsWithin-individual aggregations of a finite set of early inherited neurobehavioral susceptibilities-each individually common in the population-may account for a significant share of the heritability of ASD. Comprehensive identification of these underlying traits my help elucidate specific early intervention targets in individual patients, especially if autism represents a developmental consequence of earlier-interacting susceptibilities. Scientific understanding of the early ontogeny of autism will benefit from epidemiologically-rigorous, genetically-informative studies of robust endophenotypic candidates whose inter-relationships in infancy are mapped and normed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.