SynthesisSports medicine (Auckland, N.Z.)2019
Effect of Exercise Intervention on Cardiac Function in Type 2 Diabetes Mellitus: A Systematic Review.
Synthesis in Sports medicine (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Meta-analysis of the effects of different exercise modes on cardiac function and peak oxygen uptake in patients with type 2 diabetes mellitus.Frontiers in physiology · 2024Pooled it
- Effects of different training modes on hemodynamics and vascular endothelial function in young obese adults.Scientific reports · 2025Trial
- Impact of continuous vs. interval training on oxygen extraction and cardiac function during exercise in type 2 diabetes mellitus.European journal of applied physiology · 2022Trial
- Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses From a Randomized Clinical Trial.JAMA cardiology · 2019Trial
- Walking Improves Cardiac Function: A Trial on the Effects of Walking on Left Ventricular Function in Type 2 Diabetes Patients.Journal of cardiovascular development and disease · 2026Article
- Effects of exercise on cardiac structure and function in patients with type 2 diabetes: a narrative review of prospective imaging studies.The international journal of cardiovascular imaging · 2025Review
- Leveraging AI to Optimize Maintenance of Health Evidence and Offer a One-Stop Shop for Quality-Appraised Evidence Syntheses on the Effectiveness of Public Health Interventions: Quality Improvement Project.Journal of medical Internet research · 2025Article
- Article
- Diabetic cardiomyopathy in rats was attenuated by endurance exercise through the inhibition of inflammation and apoptosis.Heliyon · 2024Article
- Myocardial Disorders in BDNF-Deficient Rats: Limited Recovery Post-Moderate Endurance Training.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Moderate- and High-Intensity Endurance Training Alleviate Diabetes-Induced Cardiac Dysfunction in Rats.Nutrients · 2023Article
- Exercise Effects on Left Ventricular Remodeling in Patients with Cardiometabolic Risk Factors.Life (Basel, Switzerland) · 2023Review
- Article
- Aerobic Exercise Inhibited P2X7 Purinergic Receptors to Improve Cardiac Remodeling in Mice With Type 2 Diabetes.Frontiers in physiology · 2022Article
- A Contemporary Review of the Effects of Exercise Training on Cardiac Structure and Function and Cardiovascular Risk Profile: Insights From Imaging.Frontiers in cardiovascular medicine · 2022Review
- Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity.Cell death & disease · 2021Article
- Effect of Exercise Volume on Plantar Microcirculation and Tissue Hardness in People With Type 2 Diabetes.Frontiers in bioengineering and biotechnology · 2021Article
- Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?PeerJ · 2021Article
- Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe effect of exercise on cardiac function/structure in type 2 diabetes mellitus (T2DM) with or without diabetic cardiomyopathy (DCM) is not yet completely understood. To date, results of studies have been controversial with variable outcomes due to the variety of exercise modalities.
objectivesThe aim of the present review was to examine the impact of exercise intervention, and different types of exercise, on cardiac function and structure in T2DM through a systematic literature review, combining both pre-clinical and clinical studies.
methodsA systematic literature search was performed on PubMed, Web of Science, and PEDro to identify studies up to 2 April 2018. Articles were included when well-defined exercise protocols were provided, and cardiac function in T2DM patients or validated animal models was examined.
resultsIn diabetic animals, improvements in both diastolic and systolic function through exercise therapy were mainly attributed to reduced collagen deposition. In T2DM patients, improvements were observed in diastolic function, but not consistently in systolic function, after endurance (and combined resistance) exercise training. Different exercise intervention modalities and exercise types seemed equally effective in improving cardiac structure and function.
conclusionExercise training elicits significant improvements in diastolic function and beneficial remodeling in T2DM and DCM animal models, but not necessarily improvements in systolic function and left ventricular structure, regardless of exercise type. Therefore, exercise intervention should be a cornerstone in the treatment of T2DM patients not only to improve glycemic control but also to specifically enhance cardiac function.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.