ArticleBioscience reports2018
Inhibitory effect of high leucine concentration on α-amylase secretion by pancreatic acinar cells: possible key factor of proteasome.
Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Revisiting starch degradability in dairy ruminants: from feed processing to gut microbiota and metabolic regulation.Journal of animal science and biotechnology · 2026Review
- Soluble Fibrinogen-Like Protein 2 Downregulation and Th17/Treg Imbalance in a Taurocholate-Induced Murine Experimental Model of Severe Acute Pancreatitis.Journal of clinical laboratory analysis · 2024Article
- Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.World journal of gastroenterology · 2022Article
- Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Review
- Effects of dietary leucine and phenylalanine on gastrointestinal development and small intestinal enzyme activities in milk-fed holstein dairy calves.Bioscience reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to investigate whether leucine affects the pancreatic exocrine by controlling the antisecretory factor (AF) and cholecystokinin receptor (CCKR) expression as well as the proteasome activity in pancreatic acinar cells of dairy calves. The pancreatic acinar cells were isolated from newborn Holstein bull calves and cultured using the Dulbecco's modified Eagle's medium/nutrient mixture F12 Ham's liquid (DMEM/F12). There were six treatments of leucine dosage including 0 (control), 0.23, 0.45, 1.35, 4.05, and 12.15 mM, respectively. After culture for 3 h, the samples were collected for subsequent analysis. As the leucine concentration increased from 0 to 1.35 mM, the α-amylase activity in media decreased significantly (
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Registered trials
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