Trial reportClinics (Sao Paulo, Brazil)2018
Acute blood pressure responses after different isometric handgrip protocols in hypertensive patients.
Trial report in Clinics (Sao Paulo, Brazil), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05240144 (Effect of Isometric Handgrip Exercises on Blood Pressure of Hypertensive Adults), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Isometric Handgrip Exercises on Blood Pressure of Hypertensive Adults
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of long-term isometric contraction training intervention on blood pressure normalization in prehypertensive individuals: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Post-isometric exercise hypotension occurs irrespective of muscle mass in adults with hypertension: A randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2025Trial
- Effects of the Intensity, Duration, and Muscle Mass of Isometric Handgrip Exercise on Neuromuscular Fatigue and Post-Exercise Blood Pressure Responses: A Crossover Study.Health science reports · 2026Article
- Pilot Study Assessing the Hemodynamic Impact and Post-Exercise Hypotension Induced by High- Versus Low-Intensity Isometric Handgrip in Patients with Ischemic Heart Disease.Journal of cardiovascular development and disease · 2025Article
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- An evidence-based guide to the efficacy and safety of isometric resistance training in hypertension and clinical implications.Clinical hypertension · 2023Review
- Effect of isometric exercise on blood pressure in prehypertensive and hypertensive individuals: protocol for a systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2022Article
- Article
- Isometric handgrip exercise impacts only on very short-term blood pressure variability, but not on short-term blood pressure variability in hypertensive individuals: A randomized controlled trial.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study analyzed blood pressure responses after a single session of isometric handgrip exercise performed with different volumes and intensities by patients with hypertension.
methodsThis randomized crossover trial submitted 12 hypertensive patients (58±5 years old) to four isometric handgrip exercise sessions in a random order: 4 x 2 min at 30% of the maximal voluntary contraction (S30%); 4 x 2 min at 50% of the maximal voluntary contraction (S50%2min); 4 x 3 min at 30% of the maximal voluntary contraction (S30%3min); and a control session. The systolic and diastolic blood pressure, heart rate, and rate-pressure product were measured pre- and post-exercise (30th min).
resultsNo significant changes were observed in cardiovascular variables after any session (p>0.05 for all comparisons). Similarly, individual analyses revealed heterogeneity in the responses, including increases in blood pressure observed in some sessions. Patients with reduced blood pressure after an isometric handgrip exercise session exhibited a higher body mass index, diastolic blood pressure and heart rate (p<0.05). They also tended to be younger (p=0.07).
conclusionIsometric handgrip exercise performed with different intensities and volumes did not reduce the blood pressure of hypertensive patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.