Evidence map›Paper›PMID 30366310›Full record

ReviewCurrent opinion in microbiology2018

Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.

Usheer Kanjee, Gabriel W Rangel, Martha A Clark, Manoj T Duraisingh

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The Black Box of Cellular and Molecular Events ofInternational journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Frontiers in immunology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Plasmodium vivax Strains Use Alternative Pathways for Invasion.The Journal of infectious diseases · 2021
    Article
  19. Two 20-Residue-Long Peptides Derived fromInternational journal of molecular sciences · 2021
    Article
  20. Lessons Learned for Pathogenesis, Immunology, and Disease of Erythrocytic Parasites:Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Usheer KanjeeDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Gabriel W RangelDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Martha A ClarkDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Manoj T DuraisinghDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: mduraisi@hsph.harvard.edu.
Harvard University · US

Funding

Functional analysis of red blood cell determinants of Plasmodium invasionR01HL139337 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2017 to 2020
$2.3M
Elucidating ligand-receptor interactions required for Plasmodium vivax blood-stage infectionR01AI140751 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2018 to 2022
$2.0M
Red cell determinants of premature hemolysis of Plasmodium infected red cellsF32HL136173 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI CLARK, MARTHA ANN · 2017 to 2019
$186k
CIHRNHLBI NIH HHS F32 HL136173NHLBI NIH HHS R01 HL139337NIAID NIH HHS R01 AI140751
6 · The paper itself

Abstract

Plasmodium vivax is uniquely restricted to invading reticulocytes, the youngest of red blood cells. Parasite invasion relies on the sequential deployment of multiple parasite invasion ligands. Correct targeting of the host reticulocyte is mediated by two families of invasion ligands: the reticulocyte binding proteins (RBPs) and erythrocyte binding proteins (EBPs). The Duffy receptor has long been established as a key determinant for P. vivax invasion. However, recently, the RBP protein PvRBP2b has been shown to bind to transferrin receptor, which is expressed on reticulocytes but lost on normocytes, implicating the ligand-receptor in the reticulocyte tropism of P. vivax. Furthermore there is increasing evidence for P. vivax growth and sexual development in reticulocyte-enriched tissues such as the bone marrow.

Indexed as

AnimalsHost-Parasite InteractionsHumansMalaria, VivaxPlasmodium vivaxProtozoan ProteinsReticulocytesTropismProtozoan Proteins

Identifiers

PMID30366310
PMCPMC6688184
OpenAlexW2896078423

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.