ArticleScientific reports2018
Allostatic load and disordered white matter microstructure in overweight adults.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White Matter Integrity Abnormalities in Healthy Overweight Individuals Revealed by Whole Brain Meta-Analysis of Diffusion Tensor Imaging Studies.Journal of obesity · 2023Pooled it
- Do white matter hyperintensities account for the relationship between discrimination and memory?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.American journal of epidemiology · 2025Article
- White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals.Molecular psychiatry · 2025Article
- Interactions between overweight/obesity and alcohol dependence impact human brain white matter microstructure: evidence from DTI.European archives of psychiatry and clinical neuroscience · 2025Article
- Allostatic load, a measure of cumulative physiological stress, impairs brain structure but notFrontiers in aging neuroscience · 2025Article
- Obesity accelerates brain ageing: a multimodal imaging study.Brain communications · 2025Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- Neighborhood Social Environment and Body Mass Index: The Mediating Role of Mental Wellbeing.International journal of environmental research and public health · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Extended and replicated white matter changes in obesity: Voxel-based and region of interest meta-analyses of diffusion tensor imaging studies.Frontiers in nutrition · 2023Article
- Human Brain Resilience: A Call to Action.Annals of neurology · 2021Review
- Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults.Aging · 2021Article
- Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease.Journal of Parkinson's disease · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain.
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Registered trials
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