ArticleHuman brain mapping2019
Opposing patterns of neuronal variability in the sensorimotor network mediate cyclothymic and depressive temperaments.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Biological correlates of temperament: systematic reviews, empirical studies, and a conceptual framework linking neurotransmitter signaling, intrinsic brain activity, and the hyperthymic-depressive spectrum.Molecular psychiatry · 2025Pooled it
- Possible compensatory role of cerebellum in bipolar disorder. A cortical thickness study.European archives of psychiatry and clinical neuroscience · 2026Article
- Neural substrates of affective temperaments: An intersubject representational similarity analysis to resting-state functional magnetic resonance imaging in nonclinical subjects.Human brain mapping · 2024Article
- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Internalizing Symptoms and Adverse Childhood Experiences Associated With Functional Connectivity in a Middle Childhood Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- The role of community resilience as a protective factor in coping with mental disorders in a sample of psychiatric migrants.Frontiers in psychiatry · 2024Article
- Enhanced Dynamic Laterality Based on Functional Subnetworks in Patients with Bipolar Disorder.Brain sciences · 2023Article
- Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder.Psychopharmacology · 2022Article
- Resting-state neural signal variability in women with depressive disorders.Behavioural brain research · 2022Article
- Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies.Translational psychiatry · 2022Review
- Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation.Translational psychiatry · 2021Article
- Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Exploring the Effects of Temperament on Gray Matter Volume of Frontal Cortex in Patients with Mood Disorders.Neuropsychiatric disease and treatment · 2021Article
- The role of attention in the relationship between early life stress and depression.Scientific reports · 2020Article
- Opposing patterns of neuronal variability in the sensorimotor network mediate cyclothymic and depressive temperaments.Human brain mapping · 2019Article
- Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients.Frontiers in psychiatry · 2019Article
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Authors and funding
11 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Affective temperaments have been described since the early 20th century and may play a central role in psychiatric illnesses, such as bipolar disorder (BD). However, the neuronal basis of temperament is still unclear. We investigated the relationship of temperament with neuronal variability in the resting state signal-measured by fractional standard deviation (fSD) of Blood-Oxygen-Level Dependent signal-of the different large-scale networks, that is, sensorimotor network (SMN), along with default-mode, salience and central executive networks, in standard frequency band (SFB) and its sub-frequencies slow4 and slow5, in a large sample of healthy subject (HC, n = 109), as well as in the various temperamental subgroups (i.e., cyclothymic, hyperthymic, depressive, and irritable). A replication study on an independent dataset of 121 HC was then performed. SMN fSD positively correlated with cyclothymic z-score and was significantly increased in the cyclothymic temperament compared to the depressive temperament subgroups, in both SFB and slow4. We replicated our findings in the independent dataset. A relationship between cyclothymic temperament and neuronal variability, an index of intrinsic neuronal activity, in the SMN was found. Cyclothymic and depressive temperaments were associated with opposite changes in the SMN variability, resembling changes previously described in manic and depressive phases of BD. These findings shed a novel light on the neural basis of affective temperament and also carry important implications for the understanding of a potential dimensional continuum between affective temperaments and BD, on both psychological and neuronal levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.