Evidence map›Paper›PMID 30380754›Full record

ArticleInternational journal of molecular sciences2018

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice.

Mudit Mishra, Ilayaraja Muthuramu, Joseph Pierre Aboumsallem, Herman Kempen, Bart De Geest

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Clinical Insights from Proteomics in Heart Failure.Current heart failure reports · 2025
    Review
  3. Article
  4. High-Density Lipoprotein and Heart Failure.Reviews in cardiovascular medicine · 2023
    Review
  5. Review
  6. New Perspectives on Cholesterol and Lipoprotein Metabolism.International journal of molecular sciences · 2023
    Article
  7. Article
  8. HDL Composition, Heart Failure, and Its Comorbidities.Frontiers in cardiovascular medicine · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Observational
  13. Advances in HDL: Much More than Lipid Transporters.International journal of molecular sciences · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mudit MishraCentre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. mudit.mishra@kuleuven.be.
Ilayaraja MuthuramuCentre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. ilayaraja.muthuramu@kuleuven.be.ORCID 0000-0003-3550-7672
Joseph Pierre AboumsallemCentre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. josephpierre.aboumsallem@kuleuven.be.ORCID 0000-0001-8186-6620
Herman KempenThe Medicines Company (Schweiz), CH-8001 GmbH Zürich, Switzerland. hermankempen@gmail.com.ORCID 0000-0002-9915-5322
Bart De GeestCentre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. bart.degeest@kuleuven.be.ORCID 0000-0001-5580-686X
KU Leuven · BE

Funding

Fonds Wetenschappelijk Onderzoek G0A3114N
6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) represents a major unmet therapeutic need. This study investigated whether feeding coconut oil (CC diet) for 26 weeks in female C57BL/6N mice induces HFpEF and evaluated the effect of reconstituted high-density lipoprotein (HDL)

Indexed as

Heart FailureMyocardiumAnimalsApolipoprotein A-ICoronary CirculationDietary FatsDrug CombinationsFemaleHumansLipoproteins, HDLMiceMicrocirculationPhosphatidylcholinesApolipoprotein A-IDietary FatsDrug CombinationsLipoproteins, HDLMDCO-216Phosphatidylcholinesacetyl-coenzyme A carboxylasecardiac functioncardiac hypertrophycoconut oilexercise capacityheart failureHFpEFlactateReconstituted HDLtransforming growth factor-β1

Identifiers

PMID30380754
PMCPMC6274776
OpenAlexW2898941032

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.