Evidence map›Paper›PMID 30382535›Full record

SynthesisMolecular neurobiology2019

Immune Aberrations in Obsessive-Compulsive Disorder: a Systematic Review and Meta-analysis.

Theodore D Cosco, Toby Pillinger, Hadeer Emam, Marco Solmi, Sanjay Budhdeo, A Matthew Prina, Michael Maes, Dan J Stein, Brendon Stubbs, Andre F Carvalho

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
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  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 7 countries.

Theodore D CoscoGerontology Research Center, Simon Fraser University, Vancouver, Canada.
Toby PillingerDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
Hadeer EmamOlin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA.
Marco SolmiNeurosciences Department, University of Padua, Padua, Italy.
Sanjay BudhdeoNational Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
A Matthew PrinaHealth Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
Michael MaesDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Dan J SteinDepartment of Psychiatry and MRC Unit on Risk and Resilience in Mental Disorders, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Brendon Stubbs *Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London, UK.
Andre F Carvalho *Department of Psychiatry, University of Toronto, Toronto, ON, Canada. andrefc7@hotmail.com.ORCID http://orcid.org/0000-0002-4021-8675
King's College London · GBCentre for Addiction and Mental Health · CADeakin University · AUInstitute for Community Living · USNational Hospital for Neurology and Neurosurgery · GBSimon Fraser University · CAUniversity of Cape Town · ZAUniversity of Padua · IT

Funding

Department of Health ICA-CL-2017-03-001
6 · The paper itself

Abstract

Some lines of evidence have indicated that immune dysregulation could play a role in the pathophysiology of obsessive-compulsive disorder (OCD). However, results have been inconsistent across studies. Thus, a systematic review and meta-analysis of studies measuring immune mediators in participants with OCD compared to healthy controls (HC) was conducted. The PubMed/MEDLINE, PsycINFO, and EMBASE electronic databases were systematically searched from inception through June 21, 2018. Sixteen studies met inclusion criteria comprising data from 1001 participants (538 with OCD and 463 were HCs). Levels of TNF-α, IL-6, IL-1β, IL-4, IL-10, and interferon-γ did not significantly differ between participants with OCD and healthy controls. In addition, the ex vivo production of TNF-α and IL-6 by isolated macrophages did not significantly differ between participants with OCD and HCs. Nevertheless, included studies have varied in methodological quality with the enrollment of samples that differed regarding medication status, the proper matching of OCD participants and HCs, age groups, and the presence of psychiatric comorbidities. In conclusion, an association between immune dysregulation and OCD remains unproven. Future studies should consider enrolling larger and more homogeneous samples with OCD.

Indexed as

Case-Control StudiesCytokinesHumansObsessive-Compulsive DisorderCytokinesChemokinesCytokinesInflammationMeta-analysisObsessive-compulsive disorderReview

Identifiers

PMID30382535
OpenAlexW2898618688

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.