Trial reportBritish medical journal (Clinical research ed.)1987
Converting enzyme inhibition and kidney function in normotensive diabetic patients with persistent microalbuminuria.
Trial report in British medical journal (Clinical research ed.), 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 262 citations in OpenAlex.
- Angiotensin-converting-enzyme inhibitors and angiotensin receptor blockers for preventing the progression of diabetic kidney disease.The Cochrane database of systematic reviews · 2024Pooled it
- Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease.The Cochrane database of systematic reviews · 2006Pooled it
- Clinical practice guidelines for treatment of diabetes mellitus. Expert Committee of the Canadian Diabetes Advisory Board.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1992Guideline
- Lisinopril reduces postexercise albuminuria more effectively than atenolol in primary hypertension.European journal of clinical pharmacology · 1996Trial
- Effects of captopril treatment versus placebo on renal function in type 2 diabetic patients with microalbuminuria: a long-term study.The Clinical investigator · 1994Trial
- Long-term treatment with nifedipine reduces urinary albumin excretion and glomerular filtration rate in normotensive type 1 diabetic patients with microalbuminuria.Acta diabetologica · 1994Trial
- Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes.BMJ (Clinical research ed.) · 1993Trial
- A comparative study of lisinopril and atenolol on low degree urinary albumin excretion, renal function and haemodynamics in uncomplicated, primary hypertension.European journal of clinical pharmacology · 1992Trial
- Differential effects of enalapril and atenolol on proteinuria and renal haemodynamics in non-diabetic renal disease.BMJ (Clinical research ed.) · 1991Trial
- Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. Melbourne Diabetic Nephropathy Study Group.BMJ (Clinical research ed.) · 1991Trial
- Interventions in chronic renal failure.BMJ (Clinical research ed.) · 1990Trial
- Contrasting effects of enalapril and metoprolol on proteinuria in diabetic nephropathy.BMJ (Clinical research ed.) · 1990Trial
- Short term effect of captopril on microalbuminuria induced by exercise in normotensive diabetics.BMJ (Clinical research ed.) · 1989Trial
- Trial
- Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy.BMJ (Clinical research ed.) · 1988Trial
- Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria.BMJ (Clinical research ed.) · 1988Trial
- Renal haemodynamic and protective effects of renoactive drugs in type 2 diabetes: Interaction with SGLT2 inhibitors.Nephrology (Carlton, Vic.) · 2021Review
- Rates and predictors of ACE inhibitor discontinuation subsequent to elevated serum creatinine: a retrospective cohort study.BMJ open · 2014Observational
- Fetal exposure to maternal type 1 diabetes is associated with renal dysfunction at adult age.Diabetes · 2010Article
- Effect of amlodipine and lisinopril on microalbuminuria in patients with essential hypertension: A prospective study.Indian journal of nephrology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of a long term reduction in blood pressure on the kidney function of normotensive diabetic patients who had persistent microalbuminuria (30-300 mg albumin/24 hours) were studied in two groups of 10 such patients before and during six months of treatment with either 20 mg enalapril or placebo daily. Treatments were assigned randomly in a double blind fashion. Before treatment both groups had similar clinical characteristics, weight, diet, total glycosylated haemoglobin, median albumin excretion rate (enalapril group 124 mg/24 h, placebo group 81 mg/24 h), and mean arterial pressure (enalapril group 100 (SD 8) mm Hg, placebo group 99 (6) mm Hg). During treatment weight, urinary urea excretion, and total glycosylated haemoglobin remained unchanged. The mean arterial pressure decreased in the enalapril group but not in the placebo group (enalapril group 90 (10) mm Hg, placebo group 98 (8) mm Hg). The median albumin excretion rate also fell in the enalapril group but not in the placebo group (enalapril group 37 mg/24 h, placebo group 183 mg/24 h.) The glomerular filtration rate rose in the enalapril group from 130 (23) ml/min/1.73 m2 to 141 (24) ml/min/1.73 m2, and total renal resistances and fractional albumin clearance decreased while fractional albumin clearance increased in the placebo group. These results show that in patients who have diabetes but not hypertension a reduction in blood pressure by inhibition of converting enzyme for six months can reduce persistent microalbuminuria, perhaps by decreasing the intraglomerular pressure.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.