ArticleScientific reports2018
TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Spectrum and functions of ion channels and transporters in osteoclasts.Bone research · 2026Review
- Article
- Cluster-Assembled Zirconia Substrates Accelerate the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.Nanomaterials (Basel, Switzerland) · 2023Article
- Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair.Regenerative biomaterials · 2023Review
- Genome-wide association study to identify SNPs and candidate genes associated with body size traits in donkeys.Frontiers in genetics · 2023Article
- AMPK/mTOR Pathway Is Involved in Autophagy Induced by Magnesium-Incorporated TiOJournal of functional biomaterials · 2022Article
- Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.International journal of molecular sciences · 2022Article
- Review
- Magnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice.Nutrients · 2021Article
- Insights into the Role of Magnesium Ions in Affecting Osteogenic Differentiation of Mesenchymal Stem Cells.Biological trace element research · 2021Review
- A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis.International journal of molecular sciences · 2020Review
- Biological Factors, Metals, and Biomaterials Regulating Osteogenesis through Autophagy.International journal of molecular sciences · 2020Review
- TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs.BioMed research international · 2020Article
- Chemical Fingerprint of Zn-Hydroxyapatite in the Early Stages of Osteogenic Differentiation.ACS central science · 2019Article
- Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model.Materials today. Bio · 2019Article
- Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D₃.International journal of molecular sciences · 2019Article
- Biomimetic and osteogenic 3D silk fibroin composite scaffolds with nano MgO and mineralized hydroxyapatite for bone regeneration.Journal of tissue engineeringArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal stem cells are fundamental for bone formation and repair since they respond to microenvironmental stimuli by undergoing osteogenic differentiation. We show that the kinase and cation channel TRPM7 and the magnesium transporter MagT1 have a role in harmonizing the osteogenic differentiation of human mesenchymal stem cells. TRPM7 and MagT1 are upregulated in osteogenic differentiation and silencing either one accelerates osteogenic differentiation, partly through the activation of autophagy. Intriguingly, similar results were obtained when the cells were cultured under magnesium deficient conditions. These results underpin the contribution of magnesium, TRPM7 and MagT1 to autophagy and osteoblastogenesis.
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Registered trials
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