Trial reportPsychoneuroendocrinology2019
Reduced plasma ghrelin concentrations are associated with decreased brain reactivity to food cues after laparoscopic sleeve gastrectomy.
Trial report in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Laparoscopic sleeve gastrectomy improves brain connectivity in obese patients.Journal of neurology · 2020Trial
- Harnessing food cue evoked neuroimaging towards treatment optimisation for obesity and binge eating disorder.Reviews in endocrine & metabolic disorders · 2026Review
- The Influence of the Sympathetic Nervous System on Cardiometabolic Health in Response to Weight Gain or Weight Loss.Metabolites · 2025Review
- Questioning the validity of food addiction: a critical review.Frontiers in behavioral neuroscience · 2025Review
- FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery.JCI insight · 2024Article
- Obesity is associated with alterations in anatomical connectivity of frontal-corpus callosum.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Sustained improvements in brain health and metabolic markers 24 months following bariatric surgery.Brain communications · 2024Article
- Biobehavioral susceptibility for obesity in childhood: Behavioral, genetic and neuroimaging studies of appetite.Physiology & behavior · 2023Review
- Applying psycho-behavioural phenotyping in obesity characterization.Reviews in endocrine & metabolic disorders · 2023Review
- Metabolic and Bariatric Endoscopy: A Mini-Review.Life (Basel, Switzerland) · 2023Review
- Novel Insights into the Physiology of Nutrient Sensing and Gut-Brain Communication in Surgical and Experimental Obesity Therapy.Obesity surgery · 2023Review
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Postprandial Increases in Liver-Gut Hormone LEAP2 Correlate with Attenuated Eating Behavior in Adults Without Obesity.Journal of the Endocrine Society · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Neuroimaging and neuroendocrine insights into food cravings and appetite interventions in obesity.Psychoradiology · 2023Review
- Food cue reactivity: Neurobiological and behavioral underpinnings.Reviews in endocrine & metabolic disorders · 2022Review
- Alterations in Functional and Structural Connectivity of Basal Ganglia Network in Patients with Obesity.Brain topography · 2022Article
- Functional Abnormality of the Executive Control Network in Individuals With Obesity During Delay Discounting.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre-registered analysis.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 8 institutions in 2 countries.
Funding
Abstract
The "hunger" hormone ghrelin regulates food-intake and preference for high-calorie (HC) food through modulation of the mesocortico-limbic dopaminergic pathway. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery to treat morbid obesity. We tested the hypothesis that LSG-induced reductions in appetite and total ghrelin levels in blood are associated with reduced prefrontal brain reactivity to food cues. A functional magnetic resonance imaging (fMRI) cue-reactivity task with HC and low-calorie (LC) food pictures was used to investigate brain reactivity in 22 obese participants tested before and one month after bariatric surgery (BS). Nineteen obese controls (Ctr) without surgery were also tested at baseline and one-month later. LSG significantly decreased (1) fasting plasma concentrations of total ghrelin, leptin and insulin, (2) craving for HC food, and (3) brain activation in the right dorsolateral prefrontal cortex (DLPFC) in response to HC vs. LC food cues (P
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.