Evidence map›Paper›PMID 30397133›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels.

Akil A Puckerin, Donald D Chang, Zunaira Shuja, Papiya Choudhury, Joachim Scholz, Henry M Colecraft

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Rad-mediated inhibition of CaThe Journal of physiology · 2024
    Article
  3. Review
  4. Sympathetic Nervous System Regulation of Cardiac Calcium Channels.Handbook of experimental pharmacology · 2023
    Article
  5. Oxidative Regulation of Vascular CaAntioxidants (Basel, Switzerland) · 2022
    Review
  6. Inhibitory effects on L- and N-type calcium channels by a novel CaNaunyn-Schmiedeberg's archives of pharmacology · 2022
    Article
  7. Review
  8. The life cycle of voltage-gated CaNeuronal signaling · 2021
    Review
  9. The βFrontiers in cardiovascular medicine · 2021
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Akil A PuckerinDepartment of Pharmacology and Molecular Signaling, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Donald D ChangDepartment of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Zunaira ShujaDepartment of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Papiya ChoudhuryDepartment of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Joachim ScholzDepartment of Pharmacology and Molecular Signaling, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Henry M ColecraftDepartment of Pharmacology and Molecular Signaling, College of Physicians and Surgeons, Columbia University, New York, NY 10032; hc2405@cumc.columbia.edu.
Columbia University · US

Funding

Training in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7M
RGK GTPases/Ca2+ Channel Cross TalkR01HL084332 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI COLECRAFT, HENRY M. · 2007 to 2010
$1.6M
Small G-protein Regulation of Calcium ChannelsR01GM107585 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COLECRAFT, HENRY M. · 2014 to 2017
$1.2M
NHLBI NIH HHS R01 HL084332NHLBI NIH HHS T32 HL120826NIGMS NIH HHS R01 GM107585
6 · The paper itself

Abstract

Genetically encoded inhibitors for voltage-dependent Ca

Indexed as

Biophysical PhenomenaCalciumCalcium Channel BlockersCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, N-TypeHEK293 CellsHumansIon Channel GatingMonomeric GTP-Binding ProteinsMyocytes, CardiacNeuronsProtein Engineeringras ProteinsSubstrate SpecificityCalciumCalcium Channel BlockersCalcium ChannelsCalcium Channels, L-TypeCalcium Channels, N-TypeGEM protein, humanMonomeric GTP-Binding Proteinsras ProteinsREM2 protein, humanRRAD protein, humancalcium channelcalcium channel gatingCaV channelchannel inhibitionRGK GTPase

Identifiers

PMID30397133
PMCPMC6255209
OpenAlexW2899751374

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.