ArticleBrain connectivity2019
Effective Connectivity Within the Default Mode Network in Left Temporal Lobe Epilepsy: Findings from the Epilepsy Connectome Project.
Article in Brain connectivity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Abnormal functional connectivity patterns in temporal lobe epilepsy-An international ENIGMA-epilepsy study.Epilepsia open · 2026Article
- Disease detection and classification in temporal lobe epilepsy: step-wise versus simultaneous AI decision models in a multisite neuroimaging study.Brain communications · 2026Article
- Convergent functional networks of intrinsic activity alterations in temporal lobe epilepsy and their molecular correlates.Frontiers in molecular neuroscience · 2026Article
- Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI.Epilepsia · 2025Article
- Estimating brain effective connectivity from time series using recurrent neural networks.Physical and engineering sciences in medicine · 2025Article
- The relevance of Spearman'sBrain communications · 2024Article
- T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.Annals of clinical and translational neurology · 2023Article
- Multi-shell connectome DWI-based graph theory measures for the prediction of temporal lobe epilepsy and cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Subcortical Functional Connectivity Gradients in Temporal Lobe Epilepsy.medRxiv : the preprint server for health sciences · 2023Article
- DeepEZ: A Graph Convolutional Network for Automated Epileptogenic Zone Localization From Resting-State fMRI Connectivity.IEEE transactions on bio-medical engineering · 2023Article
- Functional and effective connectivity analysis of drug-resistant epilepsy: a resting-state fMRI analysis.Frontiers in neuroscience · 2023Article
- Altered Cerebro-Cerebellar Effective Connectivity in New-Onset Juvenile Myoclonic Epilepsy.Brain sciences · 2022Article
- Network phenotypes and their clinical significance in temporal lobe epilepsy using machine learning applications to morphological and functional graph theory metrics.Scientific reports · 2022Article
- Networks of cortical activity in infants with epilepsy.Brain communications · 2022Article
- Episodic Memory Dysfunction and Effective Connectivity in Adult Patients With Newly Diagnosed Nonlesional Temporal Lobe Epilepsy.Frontiers in neurology · 2022Article
- Network topology of the cognitive phenotypes of temporal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Dynamic Causal Modeling Self-Connectivity Findings in the Functional Magnetic Resonance Imaging Neuropsychiatric Literature.Frontiers in neuroscience · 2021Review
- Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity.Epilepsy & behavior : E&B · 2020Article
- Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy.NeuroImage. Clinical · 2020Article
- Comparing the Wada Test and Functional MRI for the Presurgical Evaluation of Memory in Temporal Lobe Epilepsy.Current neurology and neuroscience reports · 2019Review
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27 authors.
Funding
Abstract
The Epilepsy Connectome Project examines the differences in connectomes between temporal lobe epilepsy (TLE) patients and healthy controls. Using these data, the effective connectivity of the default mode network (DMN) in patients with left TLE compared with healthy controls was investigated using spectral dynamic causal modeling (spDCM) of resting-state functional magnetic resonance imaging data. Group comparisons were made using two parametric empirical Bayes (PEB) models. The first level of each PEB model consisted of each participant's spDCM. Two different second-level models were constructed: the first comparing effective connectivity of the groups directly and the second using the Rey Auditory Verbal Learning Test (RAVLT) delayed free recall index as a covariate at the second level to assess effective connectivity controlling for the poor memory performance of left TLE patients. After an automated search over the nested parameter space and thresholding parameters at 95% posterior probability, both models revealed numerous connections in the DMN, which lead to inhibition of the left hippocampal formation. Left hippocampal formation inhibition may be an inherent result of the left temporal epileptogenic focus as memory differences were controlled for in one model and the same connections remained. An excitatory connection from the posterior cingulate cortex to the medial prefrontal cortex was found to be concomitant with left hippocampal formation inhibition in TLE patients when including RAVLT delayed free recall at the second level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.