ArticlePLoS computational biology2018
A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Interleukin-17 as a spatiotemporal bridge from acute to chronic inflammation: Novel insights from computational modeling.WIREs mechanisms of diseasePooled it
- Mesenchymal stem cell-mediated mitochondrial transfer regulates the fate of B lymphocytes.European journal of clinical investigation · 2025Article
- Immunomodulatory Effects of L-Arginine-Modified Silkworm Pupae Protein Enteral Nutrition on Murine Intestinal Morphology and Immunity.International journal of molecular sciences · 2025Article
- Organ crosstalk and dysfunction in sepsis.Annals of intensive care · 2024Review
- Intertwined roles for GDF-15, HMGB1, and MIG/CXCL9 in Pediatric Acute Liver Failure.Frontiers in systems biology · 2024Article
- A multiscale inflammatory map: linking individual stress to societal dysfunction.Frontiers in science · 2024Article
- Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation.Frontiers in systems biology · 2024Article
- Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis.Frontiers in cell and developmental biology · 2024Article
- A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes.iScience · 2023Article
- Towards systems immunology of critical illness at scale: from single cell 'omics to digital twins.Trends in immunology · 2023Review
- The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability.Bioengineered · 2022Article
- Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling.Frontiers in immunology · 2022Article
- Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks.Molecular medicine (Cambridge, Mass.) · 2021Article
- A putative "chemokine switch" that regulates systemic acute inflammation in humans.Scientific reports · 2021Article
- IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- The Effects of Tacrolimus on Tissue-Specific, Protein-Level Inflammatory Networks in Vascularized Composite Allotransplantation.Frontiers in immunology · 2021Article
- Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p.Stem cell research & therapy · 2020Article
- Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stressAnnals of translational medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Bacterial lipopolysaccharide (LPS) induces an acute inflammatory response across multiple organs, primarily via Toll-like receptor 4 (TLR4). We sought to define novel aspects of the complex spatiotemporal dynamics of LPS-induced inflammation using computational modeling, with a special focus on the timing of pathological systemic spillover. An analysis of principal drivers of LPS-induced inflammation in the heart, gut, lung, liver, spleen, and kidney to assess organ-specific dynamics, as well as in the plasma (as an assessment of systemic spillover), was carried out using data on 20 protein-level inflammatory mediators measured over 0-48h in both C57BL/6 and TLR4-null mice. Using a suite of computational techniques, including a time-interval variant of Principal Component Analysis, we confirm key roles for cytokines such as tumor necrosis factor-α and interleukin-17A, define a temporal hierarchy of organ-localized inflammation, and infer the point at which organ-localized inflammation spills over systemically. Thus, by employing a systems biology approach, we obtain a novel perspective on the time- and organ-specific components in the propagation of acute systemic inflammation.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.