Evidence map›Paper›PMID 30401458›Full record

ArticleAmerican journal of human genetics2018

Understanding the Hidden Complexity of Latin American Population Isolates.

Jazlyn A Mooney, Christian D Huber, Susan Service, Jae Hoon Sul, Clare D Marsden, Zhongyang Zhang, Chiara Sabatti, Andrés Ruiz-Linares, Gabriel Bedoya, Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 69 citations in OpenAlex.

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  14. Unraveling the genomic diversity and admixture history of captive tigers in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
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  17. Increased homozygosity due to endogamy results in fitness consequences in a human population.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
  20. Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Jazlyn A MooneyDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Christian D HuberDepartment of Ecology & Evolutionary Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Susan ServiceCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jae Hoon SulDepartment of Psychiatry and Biobehavioral Sciences, Semel Center for Informatics and Personalized Genomics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Clare D MarsdenDepartment of Ecology & Evolutionary Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Zhongyang ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Chiara SabattiDepartment of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA; Department of Statistics, Stanford University, Stanford, CA 94305, USA.
Andrés Ruiz-LinaresMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai 200438, China; Aix-Marseille Univ, CNRS, EFS, ADES, Marseille, France.
Gabriel BedoyaGenética Molecular (GENMOL), Universidad de Antioquia, Medellín, Colombia.
Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes
Nelson FreimerCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA.
Kirk E LohmuellerDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Ecology & Evolutionary Biology, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: klohmueller@ucla.edu.
University of California, Los Angeles · USUniversidad de Antioquia · COAix-Marseille Université · FRIcahn School of Medicine at Mount Sinai · USStanford University · US

Funding

Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR · 2009 to 2018
$7.4M
Bipolar Endophenotypes in Population IsolatesR01MH075007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$3.8M
Population genomics of the selective effects of new mutationsR35GM119856 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOHMUELLER, KIRK · 2016 to 2025
$3.4M
Genome Sequencing in Extended Bipolar PedigreesR01MH095454 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2012 to 2014
$2.4M
A computational genomics approach to identify roles of rare genetic variants in psychiatric disorders and gene expressionK01ES028064 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUL, JAE HOON · 2017 to 2020
$819k
NIEHS NIH HHS K01 ES028064NIGMS NIH HHS R35 GM119856NIMH NIH HHS R01 MH075007NIMH NIH HHS R01 MH095454NINDS NIH HHS P30 NS062691
6 · The paper itself

Abstract

Most population isolates examined to date were founded from a single ancestral population. Consequently, there is limited knowledge about the demographic history of admixed population isolates. Here we investigate genomic diversity of recently admixed population isolates from Costa Rica and Colombia and compare their diversity to a benchmark population isolate, the Finnish. These Latin American isolates originated during the 16

Indexed as

ColombiaConsanguinityCosta RicaFemaleGenetics, PopulationGenome, HumanGenomicsHomozygoteHumansMalePedigreeWhite PeopleWhole Genome Sequencingdeleterious mutationsidentity by descentlinkage disequilibriumpedigreepopulation geneticspopulation isolate

Identifiers

PMID30401458
PMCPMC6218714
OpenAlexW2952862024

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.