ArticleScience (New York, N.Y.)2018
WDFY4 is required for cross-presentation in response to viral and tumor antigens.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.
0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
What it found
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Who cites it
202 citing papers in PubMed, 331 citations in OpenAlex.
- Opportunities and challenges for cancer immunotherapy based on antigen cross-presentation.Annals of medicine · 2026Review
- Oncolytic virotherapy with chimeric rVSV-NDV causes tumor-specific immunity in a DC-activation-dependent manner.Molecular therapy. Oncology · 2026Article
- Priming of CD8Nature neuroscience · 2026Article
- Tumor-induced dendritic cell deregulation perturbs T cell proliferation and predicts clinical outcome in acute lymphoblastic leukemia.Cell reports. Medicine · 2026Article
- Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.Nature biotechnology · 2026Article
- A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle-based mRNA vaccines.Science advances · 2026Article
- FLT3L-secreting cDC1 in situ vaccination enhances antitumor immunity and synergizes with PD-1 blockade in murine non-small cell lung cancer.Journal for immunotherapy of cancer · 2026Article
- Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit.Immunity · 2026Article
- The DC1 conundrum: Do type I dendritic cells make or break allograft tolerance?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- Epigenetic alterations in WDFY4 DNA methylation are linked to immunoinflammatory processes in rheumatoid arthritis: insights from a case-control study.Clinical rheumatology · 2026Article
- mRNA vaccines engage unconventional pathways in CD8Nature · 2026Article
- WDFY4 gene polymorphisms (rs11101565 and rs2671702) are not associated with breast cancer risk in Bangladeshi women: a case-control study.BMC research notes · 2026Article
- A new regulatory axis in cross-presentation: MS4A7 licenses cDC1s for effective CD8Science China. Life sciences · 2026Article
- Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity.Science (New York, N.Y.) · 2026Article
- CD20Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CD8bioRxiv : the preprint server for biology · 2026Article
- Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross-Presentation.European journal of immunology · 2026Article
- Article
- Rewiring Dendritic Cell Immunity: The β-Catenin-TIM-3 Axis as a Target to Improve DC Cancer Vaccines.Cancers · 2026Review
- The race between viral immune evasion and the MHC class I antigen processing pathway.FEMS microbiology reviews · 2026Review
142 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 2 countries.
Derek J Theisen *Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2204-8676
Jesse T Davidson *Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1099-8444
Carlos G BriseñoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marco GargaroDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.ORCID 0000-0003-0645-9800
Elvin J LauronDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-5979-9406
Qiuling WangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Pritesh DesaiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-4697-9475
Vivek DuraiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Prachi BagadiaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua R BricknerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-4620-205X
Wandy L BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0715-7361
Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8580-7628
William E GillandersDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nima MosammaparastDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8791-3165
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-7110-0285
Wayne YokoyamaDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0566-7264
Robert D SchreiberDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6311-0432
Theresa L MurphyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6539-8142
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. kmurphy@wustl.edu.ORCID 0000-0002-3505-9630
Washington University in St. Louis · USBarnes-Jewish Hospital · USHoward Hughes Medical Institute · USUniversity of Perugia · IT
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MGenetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M · 2014 to 2018
$32.7MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MHigh Throughput Production and Cryopreservation of Knockout MiceU42OD011185 · OD · JACKSON LABORATORY · PI MURRAY, STEPHEN A, TAFT, ROBERT A · 2012 to 2015
$17.9MTRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MSURGICAL ONCOLOGY TRAINING GRANTT32CA009621 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN, William E. Gillanders · 1988 to 2026
$12.9MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Megan Anne Cooper · 2018 to 2026
$7.6MT Cell Control by Cowpoxvirus U19AI109948 · NIAID · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2014 to 2018
$6.4MMECHANISM AND REGULATION OF THE DNA ALKYLATION DAMAGE RESPONSER01CA193318 · NCI · WASHINGTON UNIVERSITY · PI MOSAMMAPARAST, NIMA · 2015 to 2024
$3.6MDEVELOPMENT OF GENOMICS BASED PERSONALIZED CANCER IMMUNOTHERAPYR01CA190700 · NCI · WASHINGTON UNIVERSITY · PI SCHREIBER, ROBERT DAVID · 2015 to 2019
$2.1MThe role of cross-presentation of self-antigens by dendritic cells in type 1 diabetesF30DK108498 · NIDDK · WASHINGTON UNIVERSITY · PI DURAI, VIVEK · 2015 to 2017
$109kHoward Hughes Medical InstituteNCI NIH HHS P30 CA091842NCI NIH HHS R01 CA190700NCI NIH HHS R01 CA193318NCI NIH HHS T32 CA009621NIAID NIH HHS T32 AI007163NIAID NIH HHS U19 AI109725NIAID NIH HHS U19 AI109948NIAMS NIH HHS P30 AR073752NIDDK NIH HHS F30 DK108498NIDDK NIH HHS P30 DK020579NIH HHS U42 OD011185
Abstract
During the process of cross-presentation, viral or tumor-derived antigens are presented to CD8
Indexed as
AnimalsAntigens, NeoplasmAntigens, ViralBasic-Leucine Zipper Transcription FactorsCD8-Positive T-LymphocytesCRISPR-Cas SystemsCross-PrimingGenetic TestingHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMice, Mutant StrainsRepressor ProteinsToxoplasmaToxoplasmosisAntigens, NeoplasmAntigens, ViralBasic-Leucine Zipper Transcription FactorsIntracellular Signaling Peptides and ProteinsRepressor ProteinsSNFT protein, mouseWdfy4 protein, mouse
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.