ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Maladaptive aortic remodeling in hypertension associates with dysfunctional smooth muscle contractility.
Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Aortic Remodeling in Patients with Arterial Hypertension: Pathophysiological Mechanisms, Therapeutic Interventions and Preventive Strategies-A Position Paper from the Heart and Hypertension Working Group of the Italian Society of Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Guideline
- Article
- Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice.American journal of physiology. Heart and circulatory physiology · 2025Article
- AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice.Journal of the Royal Society, Interface · 2024Article
- Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia.Annals of biomedical engineering · 2024Article
- Biomechanical properties of the ascending aorta in patients with arterial hypertension by velocity vector imaging.The international journal of cardiovascular imaging · 2024Article
- Tempol improves aortic mechanics in a mouse model of hypertension.Journal of biomechanics · 2024Article
- TGFβ-2 haploinsufficiency causes early death in mice with Marfan syndrome.Matrix biology : journal of the International Society for Matrix Biology · 2023Article
- Vascular stiffening in aging females with a hypertension-induced HIF2A gain-of-function mutation.Bioengineering & translational medicine · 2023Article
- Intracellular signaling control of mechanical homeostasis in the aorta.Biomechanics and modeling in mechanobiology · 2022Article
- Reduced Smooth Muscle Contractile Capacity Facilitates Maladaptive Arterial Remodeling.Journal of biomechanical engineering · 2022Article
- mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II.Frontiers in cardiovascular medicine · 2022Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice.Journal of the Royal Society, Interface · 2021Article
- Sex and the G Protein-Coupled Estrogen Receptor Impact Vascular Stiffness.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta.Biomedicines · 2021Article
- Structural and functional remodeling of the femaleAmerican journal of physiology. Heart and circulatory physiology · 2021Article
- Mechanisms of Vascular Remodeling in Hypertension.American journal of hypertension · 2021Review
- Differential biomechanical responses of elastic and muscular arteries to angiotensin II-induced hypertension.Journal of biomechanics · 2021Article
- Complementary roles of mechanotransduction and inflammation in vascular homeostasis.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intramural cells are responsible for establishing, maintaining, and restoring the functional capability and structural integrity of the aortic wall. In response to hypertensive loading, these cells tend to increase wall content via extracellular matrix turnover in an attempt to return wall stress and/or material stiffness toward homeostatic values despite the elevated pressure. Using a common rodent model of induced hypertension, we found marked mouse-to-mouse differences in thoracic aortic remodeling over 2-4 wk of pressure elevation, with mechanoadaptation in some but gross maladaptation in most mice despite the same experimental conditions and overall genetic background. Consistent with our hypothesis, we also found a strong correlation between maladaptive aortic remodeling and a dysfunctional ability of the vessel to vasoconstrict, with maladaptation often evidenced by marked adventitial fibrosis. Remarkably, mouse-to-mouse variability did not correlate with the degree or duration of pressure elevation over the 2- to 4-wk study period. These findings suggest both a need to study together the structure, mechanical properties, and function across layers of the wall when assessing aortic health and a need for caution in using common statistical comparisons across small seemingly well-defined groups that may mask important underlying individual responses, an area of investigation that demands increasing attention as we move toward an era of precision diagnosis and patient care. NEW & NOTEWORTHY There are three primary findings. Marked mouse-to-mouse differences exist in large vessel hypertensive remodeling in an otherwise equivalent cohort of animals. The degree of maladaptation correlates strongly with decreases in smooth muscle contractile capacity. Finally, short-term maladaptive remodeling is independent of the precise degree or duration of the pressure elevation provided that thresholds are exceeded. Therapeutic targets should thus be personalized and focus on both layer-to-layer interactions and early interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.